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Table 3 Recurrent copy number losses in chordoma cases by aCGH

From: Frequent activation of EGFR in advanced chordomas

Regions lost in ≥ five cases
Chordoma cases (#) Cytogenetic location Frequency Candidate genes
4b, 5, 7b, 10b, 15a, 16 1pter-p33.2 0.60 RUNX3
4b, 5, 7b, 10b, 15a 1p22.3-p21.3 0.50  
3, 4b, 5, 7b, 10b, 13, 14, 16 3p24.1-p14.2 0.80 RBM5, FHIT, PTPRG
4b, 5, 7b, 9, 14 3q11.2-q13.31 0.50  
4b, 5, 7b, 9, 14 3q26.1-26.31 0.50  
3, 5, 7b,10b, 13, 14, 15a 9pter-p21 0.70 CDKN2A
3, 5, 7b, 13, 15a 9q34.11-qter 0.50 TSC1
4b, 7b, 10b, 14, 15a 10q11.23-q24.2 0.50 PTEN
5, 7b, 10b, 14, 15a 19p13.3-p13.2 0.50  
4b, 5, 9, 10b, 15a, 16 22q12.2-qter 0.60 CHEK2