Figure 2From: Expression of aromatase and estrogen receptor alpha in chondrosarcoma, but no beneficial effect of inhibiting estrogen signaling both in vitro and in vivoCell viability assays measuring the effect of estrogen and antiestrogens in chondrosarcoma cell lines. A) Unlike breast cancer cell line ZR-75-1, chondrosarcoma cell lines (SW1353, CH2879, OUMS27, and JJ012) and primary cultures (L869 and L835) did not respond to E2 with increased proliferation; B) also none of these cultures responded to 4-hydroxytamoxifen (OHT), and fulvestrant (Fulv) in the presence of 1 nM E2. Only L835, which is representative, is shown.Back to article page