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Table 3 Number of cycles complicated by grade 3 or 4 toxicity out of the total of 193 delivered cycles of VDC/IE

From: Interval compressed vincristine, doxorubicin, cyclophosphamide alternating with ifosfamide, etoposide in patients with advanced Ewing’s and other Small Round Cell Sarcomas

Grade 3 & 4 Toxicity rates/193 cycles

Grade 3

Grade 4

Total Grade 3 and 4 (%)

Febrile Neutropenia

26

0

26 (13.5)

Non-febrile neutropenia

3

11

14 (7.3)

Anaemia

29

2

31 (16.1)

Thrombocytopenia

19

6

25 (13.0)

Mucositis

12

0

12 (6.2)

Non-neutropenic infection requiring hospital admission

6

0

6 (3.1)

Neuropathy

3

0

3 (1.6)

Fatigue

3

0

3 (1.6)

Diarrhoea

2

0

2 (1.0)

Nausea and vomiting

2

0

2 (1.0)