From: Mesenchymal stem cell transformation and sarcoma genesis
Sarcoma type | Cell of origin | Targeted genes | Reference |
---|---|---|---|
Osteosarcoma | Mouse BMMSCs | - | [4] |
- | [6] | ||
C-myc overexpression and Ink4a/Arf knockout | [16] | ||
Mouse osteoblast precursors | Tp53, Rb double knockout | [56] | |
Mouse osteoblasts | Tp53 knockout | [57] | |
Tp53 and Rb double knockout [57] | |||
Tp53 knockout | [17] | ||
Leiomyosarcomas | Mouse AMSCs | Tp53 knockout | [14] |
Tp53 knockout | [24] | ||
Tp53 and Rb double knockout [8] | |||
Mouse smooth muscle lineage cells | Pten knockout | [30] | |
“Fibrosarcoma” | Mouse BMMSCs | - | [58] |
Aged mouse BMMSCs | - | [25] | |
Mouse AMSCs | P21 knockout, Tp53 heterozygous knockout | [24] | |
Pleomorphic rhabdomyosarcoma | Mouse skeletal muscle cells | K-ras overexpression and Tp53 knockout | [32] |
K- ras overexpression and Tp53 heterozygous knockout [32] |