Fig. 3
From: High-grade soft tissue sarcoma arising in a desmoid tumor: case report and review of the literature
Pathological aspect of the surgical specimen containing the desmoid tumor and the sarcoma. a Macroscopic aspect: an ill-defined fibrous-like area occupies most of the specimen, with contact to resection margin (arrow). Within this lesion two less fibrous areas are identified (black lines). These ones correspond to high-grade sarcoma zones on microscopic examination. b Microscopic aspect (HES) showing abrupt transition between high grade sarcoma (left) and DT (right). c Microscopic aspect (HES) showing the DT: spindle cell proliferation of fibroblastic-like cells, interspersed within a collagenous matrix. Spindle cells are void of cytological atypia, and no mitosis or necrosis are seen. d Microscopic aspect (HES) showing the high grade sarcoma area. The neoplastic proliferation is more cellular and dense. Spindle cells are disposed in sheets infiltrating the skeletal muscle bundles. They appear small with indistinct cytoplasmic limits; nuclei are oval or round and display dense chromatin. Mitoses are easily found (black arrow)