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Table 10 Hazard ratios (CCLG vs. GPOH) according to local treatment modality, among patients with localised disease only

From: Survival is influenced by approaches to local treatment of Ewing sarcoma within an international randomised controlled trial: analysis of EICESS-92

 

Local treatment modality

Subdivision of RT and surgery group

Radiotherapy (RT) alone

N = 108

Surgery alone

N = 119

RT and surgery

N = 221

RT then surgery

N = 152

Surgery then RT

N = 69

No. events

 EFS

62

42

83

61

22

 OS

53

33

66

49

17

Unadjusted

 EFS

0.89 (0.54–1.46)

1.44 (0.78–2.64)

1.66 (0.94–2.96)

2.44 (0.76–7.81)

2.36 (1.02–5.45)

 OS

0.99 (0.56–1.64)

1.74 (0.86–3.51)

1.60 (0.84–3.06)

2.70 (0.84–8.73)

2.03 (0.78–5.28)

Adjusted for age, primary site and histology

 EFS

0.98 (0.58–1.66)

1.51 (0.78–2.94)

1.65 (0.91–2.99)

2.39 (0.71–8.05)

2.12 (0.83–5.40)

 OS

1.10 (0.62–1.95)

1.94 (0.89–4.25)

1.50 (0.77–2.93)

3.10 (0.90–10.70)

1.74 (0.60–5.08)

Adjusted for age, primary site, histology and time between the start of chemotherapy and starting local treatment

 EFS

0.95 (0.54–1.67)

1.48 (0.76–2.89)

1.48 (0.81–2.69)

1.69 (0.50–5.68)

2.10 (0.82–5.41)

 OS

1.03 (0.55–1.90)

1.92 (0.87–4.24)

1.39 (0.71–2.74)

2.49 (0.72–8.58)

1.74 (0.59–5.10)

  1. Hazard ratios greater than 1 indicate that CCLG patients had a higher risk of having an event or dying compared to GPOH patients
  2. Based on data excluding patients with unknown primary site because there were so few
  3. EFS event-free survival; OS overall survival