Table 2 Adverse events
Group | Toxicity | Grade 3 | Grade 4 | Total | Dose level |
|---|---|---|---|---|---|
Hematologic | Thrombocytopenia | 3 | 3 | 6 | 4 |
Neutropenia | 5 | – | 5 | 4 | |
Lymphocyte count decreased | 1 | – | 1 | 4 | |
White blood cell decreased | 1 | – | 1 | 4 | |
Gastrointestinal | Lipase increased | – | 3 | 3 | 4 |
ALT increased | 3 | – | 3 | 4 | |
Vomiting | 3 | – | 3 | 4, 5 | |
Serum Amylase increased | 2 | – | 2 | 4 | |
Abdominal pain | 1 | – | 1 | 5 | |
Anorexia | – | 1 | 1 | 5 | |
AST increased | 1 | – | 1 | 4 | |
Stomatitis | 1 | – | 1 | 4 | |
Weight loss | 1 | – | 1 | 4 | |
Metabolic | Hypophosphatemia | 6 | – | 6 | 4, 5 |
Hypokalemia | 2 | – | 2 | 4, 5 | |
Hypocalcemia | 1 | – | 1 | 4 | |
Hyponatremia | 1 | – | 1 | 4 | |
Other | Bone infection | 1 | – | 1 | 4 |