Fig. 2

γ-Radioresistance in chondrosarcoma tissues correlates with mutations in cell cycle related genes. a L5213 chondrosarcoma tissue sample showing a large induction of γH2AX foci after5 Gy(right) compared to controls (right). b Amount of foci/cell in sample L5213 after 5 Gy radiation compared to controls. c Protein expression of Bcl-2, Bcl-xl, Survivin, P-S6, LC3B and P53 in highly radioresistant (< 4 foci difference) compared to less radioresistant (> 4 foci difference) chondrosarcomas. d Difference between mean amount of γH2AX foci before and after radiation in chondrosarcomas with and without alterations in RB1 or CDKN2A. Each dot represents one sample. Samples in green indicate 2 h, while samples in blue indicate samples 24 h after radiation