Table 4 Cases and controls: development sample—diagnoses, treatments, procedures, symptoms at index cancer diagnosis
Controls N = 1,800,079 | Cases N = 10,906 | |
|---|---|---|
Cancer diagnoses following index | ||
STS diagnosis, N (%) | 11,054 (0.6%) | 7590 (69.6%) |
Number of STS diagnoses, mean (SD) | 0.0 (0.9) | 12.6 (20.0) |
Non-STS cancer diagnosis, N (%) | 1593,963 (88.6%) | 8115 (74.4%) |
Number of non-STS cancer diagnoses, mean (SD) | 14.5 (16.7) | 10.5 (15.2) |
Treatments | ||
Any STS NCCN recommended treatment prior to index, N (%) | 209,021 (11.6%) | 2674 (24.5%) |
Any STS NCCN recommended treatment following index, N (%) | 171,301 (9.5%) | 2548 (23.4%) |
Days from index diagnosis date to treatment, mean (SD) | 32.0 (42.0) | 35.1 (43.6) |
Regimen type, among those with treatment, N (%) | ||
NCCN recommended single agent | 163,261 (95.3%) | 1154 (45.3%) |
NCCN combination regimen | 2819 (1.7%) | 1164 (45.7%) |
Not a valid single agent or combination regimen | 5221 (3.1%) | 230 (9.0%) |
Symptoms measured prior to index, N (%) | ||
Neoplasm of uncertain behavior in skin | 117,979 (6.6%) | 696 (6.4%) |
Pain in limb | 129,494 (7.2%) | 1097 (10.1%) |
Localized superficial swelling mass lump | 15,017 (0.8%) | 967 (8.9%) |
Days from symptom to index, mean (SD) | ||
Neoplasm of uncertain behavior in skin | 65.7 (49.7) | 84.6 (50.2) |
Pain in limb | 76.0 (51.7) | 74.6 (54.3) |
Localized superficial swelling mass lump | 79.9 (50.5) | 89.4 (50.4) |
Post diagnosis surgical procedures, N (%) | ||
Excision surgery | 377,857 (21.0%) | 2055 (18.8%) |
Resection surgery | 194,687 (10.8%) | 1189 (10.9%) |
Number of procedures, mean (SD) | ||
Excision surgery | 1.4 (0.9) | 1.4 (0.9) |
Resection surgery | 1.1 (0.4) | 1.1 (0.5) |
Pre-diagnosis surgical procedures, N (%) | ||
Excision surgery | 485,480 (27.0%) | 3552 (32.6%) |
Resection surgery | 285,294 (15.9%) | 2341 (21.5%) |
Number of procedures, mean (SD) | ||
Excision surgery | 1.4 (0.8) | 1.4 (0.8) |
Resection surgery | 1.1 (0.4) | 1.1 (0.4) |
Imaging scans (measured prior to or on index), N (%) | ||
Computerized tomography scan | 1,051,001 (58.4%) | 9401 (86.2%) |
Magnetic resonance imaging | 445,463 (24.8%) | 4785 (43.9%) |
Radiograph | 1,135,315 (63.1%) | 7797 (71.5%) |
Positron-emission tomography scan | 328,534 (18.3%) | 3487 (32.0%) |
Number of tests, mean (SD) | ||
Computerized tomography scan | 3.7 (6.4) | 4.5 (6.1) |
Magnetic resonance imaging | 1.4 (0.9) | 1.5 (0.8) |
Radiograph | 2.3 (1.9) | 2.5 (1.9) |
Positron-emission tomography scan | 1.2 (0.4) | 1.4 (0.6) |
Number of different scans, mean (SD) | 4.1 (5.9) | 6.8 (6.6) |