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Table 4 Cases and controls: development sample—diagnoses, treatments, procedures, symptoms at index cancer diagnosis

From: Evaluation of the accuracy of algorithms to identify soft tissue sarcoma (STS) in administrative claims

 Controls
N = 1,800,079
Cases
N = 10,906
Cancer diagnoses following index
 STS diagnosis, N (%)11,054 (0.6%)7590 (69.6%)
 Number of STS diagnoses, mean (SD)0.0 (0.9)12.6 (20.0)
 Non-STS cancer diagnosis, N (%)1593,963 (88.6%)8115 (74.4%)
 Number of non-STS cancer diagnoses, mean (SD)14.5 (16.7)10.5 (15.2)
Treatments
 Any STS NCCN recommended treatment prior to index, N (%)209,021 (11.6%)2674 (24.5%)
 Any STS NCCN recommended treatment following index, N (%)171,301 (9.5%)2548 (23.4%)
 Days from index diagnosis date to treatment, mean (SD)32.0 (42.0)35.1 (43.6)
 Regimen type, among those with treatment, N (%)
  NCCN recommended single agent163,261 (95.3%)1154 (45.3%)
  NCCN combination regimen2819 (1.7%)1164 (45.7%)
  Not a valid single agent or combination regimen5221 (3.1%)230 (9.0%)
Symptoms measured prior to index, N (%)
 Neoplasm of uncertain behavior in skin117,979 (6.6%)696 (6.4%)
 Pain in limb129,494 (7.2%)1097 (10.1%)
 Localized superficial swelling mass lump15,017 (0.8%)967 (8.9%)
Days from symptom to index, mean (SD)
 Neoplasm of uncertain behavior in skin65.7 (49.7)84.6 (50.2)
 Pain in limb76.0 (51.7)74.6 (54.3)
 Localized superficial swelling mass lump79.9 (50.5)89.4 (50.4)
Post diagnosis surgical procedures, N (%)
 Excision surgery377,857 (21.0%)2055 (18.8%)
 Resection surgery194,687 (10.8%)1189 (10.9%)
 Number of procedures, mean (SD)  
  Excision surgery1.4 (0.9)1.4 (0.9)
  Resection surgery1.1 (0.4)1.1 (0.5)
Pre-diagnosis surgical procedures, N (%)
 Excision surgery485,480 (27.0%)3552 (32.6%)
 Resection surgery285,294 (15.9%)2341 (21.5%)
 Number of procedures, mean (SD)
  Excision surgery1.4 (0.8)1.4 (0.8)
  Resection surgery1.1 (0.4)1.1 (0.4)
Imaging scans (measured prior to or on index), N (%)
 Computerized tomography scan1,051,001 (58.4%)9401 (86.2%)
 Magnetic resonance imaging445,463 (24.8%)4785 (43.9%)
 Radiograph1,135,315 (63.1%)7797 (71.5%)
 Positron-emission tomography scan328,534 (18.3%)3487 (32.0%)
 Number of tests, mean (SD)
  Computerized tomography scan3.7 (6.4)4.5 (6.1)
  Magnetic resonance imaging1.4 (0.9)1.5 (0.8)
  Radiograph2.3 (1.9)2.5 (1.9)
  Positron-emission tomography scan1.2 (0.4)1.4 (0.6)
 Number of different scans, mean (SD)4.1 (5.9)6.8 (6.6)