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Fig. 3 | Clinical Sarcoma Research

Fig. 3

From: Successful treatment of lipofibromatosis-like neural tumor of the lumbar spine with an NTRK-fusion inhibitor

Fig. 3

LMNA-NTRK1 fusion confirmed by RT-PCR. a Schematic diagram showing the predicted in-frame LMNA-NTRK1 fusion protein joining the 5′ LMNA filament domain to an intact 3′ NTRK1 tyrosine kinase domain (KD). The red dashed lines denote the 1q chromosomal positions of LMNA and NTRK1, respectively. b RT-PCR Sanger sequencing trace confirming the fusion breakpoint at chr1:156100564 (LMNA, NM_005572.3, exon 2) and chr1:156844698 (NTRK1, NM_002529.3, exon 11). LTD, lamin tail domain; Ig, Tyrosine-protein kinase receptor C2 Ig-like domain

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Clinical Sarcoma Research

ISSN: 2045-3329