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Table 3 Tumour and treatment characteristics

From: Survival of soft tissue sarcoma patients after completing six cycles of first-line anthracycline containing treatment: an EORTC-STBSG database study

  Less than 6 cycles Exactly 6 cycles More than 6 cycles Exactly 6 cycles—no PD
PD before end of treatment (N = 567) No PD before end of treatment (N = 584) Total (N = 1151) PD before end of treatment (N = 80) No PD before end of treatment (N = 475) Total (N = 555) PD before end of treatment (N = 66) No PD before end of treatment (N = 273) Total (N = 339) Treatment
DOX 75 (N = 223) DOX 50-IFO 5 (N = 80) DOX 75-IFO 5 (N = 63) DOX 75-IFO 10 (N = 109) Total (N = 475)
N (%) N (%) N (%) N (%) N (%) N (%) N (%) N (%) N (%) N (%) N (%) N (%) N (%) N (%)
Histopathological grading
 Grade I and II 38 (6.7) 30 (5.1) 68 (5.9) 6 (7.5) 52 (10.9) 58 (10.5) 8 (12.1) 24 (8.8) 32 (9.4) 26 (11.7) 12 (15.0) 8 (12.7) 6 (5.5) 52 (10.9)
 Grade III 331 (58.4) 366 (62.7) 697 (60.6) 46 (57.5) 331 (69.7) 377 (67.9) 33 (50.0) 152 (55.7) 185 (54.6) 158 (70.9) 38 (47.5) 33 (52.4) 102 (93.6) 331 (69.7)
 Missing 198 (34.9) 188 (32.2) 386 (33.5) 28 (35.0) 92 (19.4) 120 (21.6) 25 (37.9) 97 (35.5) 122 (36.0) 39 (17.5) 30 (37.5) 22 (34.9) 1 (0.9) 92 (19.4)
Site of primary tumour
 Other 284 (50.1) 257 (44.0) 541 (47.0) 32 (40.0) 245 (51.6) 277 (49.9) 26 (39.4) 106 (38.8) 132 (38.9) 130 (58.3) 40 (50.0) 17 (27.0) 58 (53.2) 245 (51.6)
 Extremities 129 (22.8) 143 (24.5) 272 (23.6) 27 (33.8) 152 (32.0) 179 (32.3) 17 (25.8) 73 (26.7) 90 (26.5) 76 (34.1) 15 (18.8) 12 (19.0) 49 (45.0) 152 (32.0)
 Missing 154 (27.2) 184 (31.5) 338 (29.4) 21 (26.3) 78 (16.4) 99 (17.8) 23 (34.8) 94 (34.4) 117 (34.5) 17 (7.6) 25 (31.3) 34 (54.0) 2 (1.8) 78 (16.4)
Histology
 Leiomyosarcoma 192 (33.9) 180 (30.8) 372 (32.3) 23 (28.8) 128 (26.9) 151 (27.2) 25 (37.9) 79 (28.9) 104 (30.7) 66 (29.6) 25 (31.3) 13 (20.6) 24 (22.0) 128 (26.9)
 Synovial sarcoma 32 (5.6) 59 (10.1) 91 (7.9) 10 (12.5) 71 (14.9) 81 (14.6) 6 (9.1) 29 (10.6) 35 (10.3) 37 (16.6) 8 (10.0) 7 (11.1) 19 (17.4) 71 (14.9)
 Other 315 (55.6) 317 (54.3) 632 (54.9) 44 (55.0) 266 (56.0) 310 (55.9) 35 (53.0) 151 (55.3) 186 (54.9) 119 (53.4) 42 (52.5) 40 (63.5) 65 (59.6) 266 (56.0)
 Missing 28 (4.9) 28 (4.8) 56 (4.9) 3 (3.8) 10 (2.1) 13 (2.3) 0 (0.0) 14 (5.1) 14 (4.1) 1 (0.4) 5 (6.3) 3 (4.8) 1 (0.9) 10 (2.1)
Prior surgery
 No surgery 60 (10.6) 57 (9.8) 117 (10.2) 10 (12.5) 19 (4.0) 29 (5.2) 3 (4.5) 25 (9.2) 28 (8.3) 8 (3.6) 11 (13.8) 0 (0.0) 0 (0.0) 19 (4.0)
 Non optimal surgery 104 (18.3) 77 (13.2) 181 (15.7) 18 (22.5) 23 (4.8) 41 (7.4) 10 (15.2) 64 (23.4) 74 (21.8) 11 (4.9) 12 (15.0) 0 (0.0) 0 (0.0) 23 (4.8)
 Complete surgery 155 (27.3) 128 (21.9) 283 (24.6) 13 (16.3) 66 (13.9) 79 (14.2) 35 (53.0) 106 (38.8) 141 (41.6) 42 (18.8) 24 (30.0) 0 (0.0) 0 (0.0) 66 (13.9)
 Unknown 248 (43.7) 322 (55.1) 570 (49.5) 39 (48.8) 367 (77.3) 406 (73.2) 18 (27.3) 78 (28.6) 96 (28.3) 162 (72.6) 33 (41.3) 63 (100.0) 109 (100.0) 367 (77.3)
Prior radiotherapy
 No 435 (76.7) 390 (66.8) 825 (71.7) 58 (72.5) 279 (58.7) 337 (60.7) 43 (65.2) 191 (70.0) 234 (69.0) 115 (51.6) 57 (71.3) 41 (65.1) 66 (60.6) 279 (58.7)
 Yes 119 (21.0) 171 (29.3) 290 (25.2) 19 (23.8) 153 (32.2) 172 (31.0) 23 (34.8) 82 (30.0) 105 (31.0) 66 (29.6) 22 (27.5) 22 (34.9) 43 (39.4) 153 (32.2)
 Missing 13 (2.3) 23 (3.9) 36 (3.1) 3 (3.8) 43 (9.1) 46 (8.3) 0 (0) 0 (0) 0 (0) 42 (18.8) 1 (1.3) 0 (0.0) 0 (0.0) 43 (9.1)
Primary site involved
 No 195 (34.4) 219 (37.5) 414 (36.0) 35 (43.8) 244 (51.4) 279 (50.3) 36 (54.5) 112 (41.0) 148 (43.7) 122 (54.7) 42 (52.5) 22 (34.9) 58 (53.2) 244 (51.4)
 Yes 310 (54.7) 288 (49.3) 598 (52.0) 37 (46.3) 192 (40.4) 229 (41.3) 25 (37.9) 133 (48.7) 158 (46.6) 86 (38.6) 38 (47.5) 17 (27.0) 51 (46.8) 192 (40.4)
 Missing 62 (10.9) 77 (13.2) 139 (12.1) 8 (10.0) 39 (8.2) 47 (8.5) 5 (7.6) 28 (10.3) 33 (9.7) 15 (6.7) 0 (0.0) 24 (38.1) 0 (0.0) 39 (8.2)
Metastatic site involved
 No 79 (13.9) 99 (17.0) 178 (15.5) 10 (12.5) 49 (10.3) 59 (10.6) 10 (15.2) 45 (16.5) 55 (16.2) 22 (9.9) 14 (17.5) 5 (7.9) 8 (7.3) 49 (10.3)
 Yes 426 (75.1) 408 (69.9) 834 (72.5) 62 (77.5) 387 (81.5) 449 (80.9) 51 (77.3) 200 (73.3) 251 (74.0) 186 (83.4) 66 (82.5) 34 (54.0) 101 (92.7) 387 (81.5)
 Missing 62 (10.9) 77 (13.2) 139 (12.1) 8 (10.0) 39 (8.2) 47 (8.5) 5 (7.6) 28 (10.3) 33 (9.7) 15 (6.7) 0 (0.0) 24 (38.1) 0 (0.0) 39 (8.2)