- Case Report
- Open Access
Descending thoracic aortic aneurysm revealing metastasis of a soft tissue fibrosarcoma: a case report and review of the literature
© The Author(s) 2018
- Received: 5 October 2017
- Accepted: 6 October 2018
- Published: 26 October 2018
Review of the first documented case of aortic wall metastasis from a limb sarcoma.
In a 56-year-old woman with a diagnosis of a high-grade limb fibrosarcoma, an aortic metastasis was revealed by a fast growing aneurysm of the descending thoracic aorta. This was managed with an endoprosthesis.
The presence of an aneurysm in a patient with a sarcoma with a high potential for metastasis and poor cardiovascular risk factors should alert physicians.
- Soft tissue sarcoma
- Aortic aneurysm
- Aortic metastasis
Soft-tissue sarcoma is a rare entity (it represents less than 1% of malignant tumors ). These tumors have a propensity for locally destructive growth and recurrence, and 20% to almost 100% of them have a significant risk of distant metastasis, depending on their histological type and grade. One-tenth of soft-tissue sarcomas are already in a metastatic state when discovered . Due to the poor prognosis in the case of metastatic neoplasia , a baseline CT scan is recommended for tumor staging, especially for sarcomas measuring more than five centimeters. Recent studies also suggest that positron emission tomography (PET) may be clinically indicated to evaluate biological activity in soft tissue masses , but this technique can lead to false positives due to its low specificity in the case of infectious or active inflammatory processes. There are no clear current guidelines regarding management of metastatic sarcoma .
Typically, metastatic sarcomas are considered incurable and palliative treatment, including chemotherapy, is performed (for performance status = 0–2). Tumors spread primarily through the vascular system, and lungs are the most common site for distant metastasis. To our knowledge, an aortic metastasis of a sarcoma has not yet been described as primary intimal sarcomas are most commonly reported in the literature . In this report, we describe a case of aortic metastasis of a limb fibrosarcoma revealed by a descending thoracic aortic aneurysm, and its management.
A thoracoabdominal CT scan was performed for tumor staging and found a 35-mm saccular aneurysm of the descending thoracic aorta (Fig. 1b–d). The patient, despite her age, had no cardiovascular risk factors. A PET-CT performed 1 month later showed a suspicious contralateral limb metastasis and abnormal aortic FDG uptake around the aneurysm, which could be attributed to an infectious or tumorous process (Fig. 1e). Follow-up CT scans showed quick growth of the aneurysm from 35 to 49 mm. The patient was then transferred for endovascular aortic repair with an endoprosthesis (Fig. 1f) measuring 28 × 164 mm (Relay NBS® Bolton Medical). The presence of an atypical epigastric artery angiogram led to an artery biopsy during the procedure, which found no evidence of dysplasia. Despite negative blood samples taken near the aneurysm, the possibility of an infectious location was discussed due to the patient’s poor dental condition. Postoperative probabilistic antibiotic treatment was started with oxacillin and ofloxacin, and then amoxicillin.
Surgical resection of the primary tumor was rejected due to histological confirmation of a right gluteal metastasis (contralateral). Initially, the patient received conventional chemotherapy by doxorubicin and ifosfamide, but the treatment was quickly switched to cisplatin and paclitaxel due to tumor progression. The patient was then included in a clinical trial (NCT01308034 Study of Continuous Dosing of Sunitinib in Non GIST Sarcomas with Concomitant Radiotherapy) and treatment by sunitinib was introduced with concomitant radiotherapy. Due to adverse effects that led to a deep thrombocytopenia (50 G/L), sunitinib was stopped.
The luminal-type intimal sarcoma (IS) is the most common sarcoma of the aorta . In the early stages, tumor aneurysms are very similar to atherosclerotic aneurysms on CT findings, which often leads to a delay in diagnosis. Tumor etiology must be considered in the case of low cardiovascular risk factors, atypical imaging findings or a rapidly evolving aneurysm. In the late stages, multiplanar imaging often helps to discriminate tumor tissues from atherosclerotic materials and shows enhancing lesions around the aneurysm and tumor extending into the aortic wall or adjacent structures.
Sarcoma survival rates are closely linked to their potential metastasis risk. Since 2002, the World Health Organization (WHO) Classification of Tumors of Soft Tissue and Bone divided these tumors into three risk groups: benign, intermediate (locally aggressive or rarely metastasizing) and malignant. This classification helps physicians adapt treatment according to the risk of tumor metastasis. There are no current guidelines regarding initial tumor staging, but the WHO clearly recommends multidisciplinary decision-making. Sarcomas spread primarily through the vascular system, and the lungs are the most common site for distant metastasis. Patients at high risk of metastasis usually have an initial chest CT scan; a thoracoabdominal CT scan may be also performed.
Sarcoma rarely metastasizes to the skin, soft tissues, liver or lymph nodes (3%). Primary aortic sarcomas are rare tumors, with approximately 30 cases reported in the literature .
Typically, patients with aortic intimal sarcomas have symptoms caused by tumor emboli including pulseless extremities or abdominal pain, rather than symptoms directly related to the primary tumor . In our case, the patient was asymptomatic and there was no evidence of aortic lumen obstruction.
[18F]-2-Fluorodeoxyglucose (FDG) is the most commonly used tracer for PET imaging. This is a glucose analog that accumulates in cells and FDG uptake reflects tissue metabolic activity. In oncology, it is used to detect metastases by virtue of their metabolic differences compared to surrounding normal tissue. False positives commonly occur with active inflammatory or infectious lesions and false negatives occur with low metabolic activity tumors or small lesions (< 1 cm), due to limited resolution. In our case, PET-CT was used in conjunction with initial CT scan as a complementary diagnostic tool and showed intense FDG uptake around the aneurysm. However, in the case of rapidly evolving atherosclerotic aneurysms, FDG uptake can also be seen. An aortic metastatic localization was not initially considered to be the most likely diagnosis in our case. Follow-up CT scans and MRI findings found enhanced tissues around the aneurysm.
The endovascular treatment of aortic aneurysms is now the gold standard to avoid the risk of rupture beyond 5 cm. In this case, simple monitoring was impossible in view of rapid progression, and the multidisciplinary team judged open surgery to be inappropriate and too invasive.
To our knowledge, an aortic metastasis of a sarcoma has not yet been reported in the literature. Immunohistochemical tests are needed to discriminate primary intimal sarcomas from other aortic tumors. Indeed, intimal sarcomas do not express epithelial, smooth muscle, or schwannoma-like markers and are positive for mesenchymal marker, vimentin. In our case, pan cytokeratin and smooth muscle actin markers were positive, similar to the primitive limb sarcoma.
Aortic metastases of limb sarcoma are rare. In the early stages, tumor aneurysms are very similar to atherosclerotic aneurysms on CT findings, which often lead to a delay in diagnosis. The atypical localization of the aneurysm, low cardiovascular risk factors, rapidly evolving aneurysm and enhanced tissues around the aorta are suspicious findings for aortic metastasis. FDG uptake around the aneurysm, although not specific, can contribute to the diagnosis.
CD, AB, OB and CM were major contributor in writing the manuscript. FP reviewed manuscript. SC was a contributor in selecting and formatting figures. AT performed medical charts review to regarding medical history and worked on figures. All authors read and approved the final manuscript.
The authors declare that they have no competing interests.
Availability of data and materials
The datasets used and/or analysed during the current study available from the corresponding author on reasonable request.
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- Hallahan DE, Vogelzang NJ, Borow KM, Bostwick DG, Simon MA. Cardiac metastases from soft-tissue sarcomas. J Clin Oncol. 1986;11:1662–9.View ArticleGoogle Scholar
- Fletcher CDM, Unni KK, Mertens F. Pathology and genetics of tumours of soft tissue and bone. Lyon: IARC press; 2002.Google Scholar
- Gerrand CH, Billingham LJ, Woll PJ, Grimer RJ. Follow up after primary treatment of soft tissue sarcoma: a survey of current practice in the United Kingdom. Sarcoma. 2007;2007:602–12.View ArticleGoogle Scholar
- Dimitrakopoulou-Strauss A, Strauss LG, Schwarzbach M, Burger C, Heichel T, Willeke F, Mechtersheimer G, Lehnert T. Dynamic PET 18F-FDG studies in patients with primary and recurrent soft-tissue sarcomas: impact on diagnosis and correlation. J Nucl Med. 2001;42:713–20.PubMedGoogle Scholar
- ESMO (European Sarcoma Network Working Group). Soft tissue and visceral sarcomas: ESMO-EURACAN clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2018;29:51–67.View ArticleGoogle Scholar
- Thalheimer Andreas, Fein Martin, Geissinger Eva, Franke Siegfried. Intimal angiosarcoma of the aorta: report of a case and review of the literature. J Vasc Surg. 2004;40:548–53.View ArticleGoogle Scholar
- Sebenik M, Ricci A Jr, DiPasquale B, Mody K, Pytel P, Jee KJ, Knuutila S, Scholes J. Undifferentiated intimal sarcoma of large systemic blood vessels: report of 14 cases with immunohistochemical profile and review of the literature. Am J Surg Pathol. 2005;29:1184–93.View ArticleGoogle Scholar
- Böhner Hinrich, Luther Bernd, Braunstein Stefan, Beer Sandra, Sandmann Wilhelm. Primary malignant tumors of the aorta: clinical presentation, treatment, and course of different entities. J Vasc Surg. 2003;38:1430–3.View ArticleGoogle Scholar
- Seelig MH, Klingler PJ, Oldenburg WA, et al. Angiosarcoma of the aorta: report of a case and review of the literature. J Vasc Surg. 1998;28:732–7.View ArticleGoogle Scholar