- Open Access
Antiangiogenic effects in patients with progressive desmoplastic small round cell tumor: data from the French national registry dedicated to the use of off-labeled targeted therapy in sarcoma (OUTC’s)
Clinical Sarcoma Research volume 7, Article number: 10 (2017)
Desmoplastic small round cell tumor (DSRCT) is a very rare mesenchymal tumor that mainly affects teenagers and young adults with a mean age at diagnosis around 20–25 years. Although initial management still needs standardization, many centers will use multimodal treatment including intensive chemotherapy, extensive surgical resection followed by radiotherapy. Despite this, prognosis remains very poor and the median overall survival is 25 months. Recurrent disease is mainly treated by chemotherapy. Recently, due to the unmet medical need for recurrent disease, targeted therapies were explored for DSRCT.
In this study, we assessed the response rate and progression free survival in nine cases of progressive DSRCT included in the OUTC’s registry and treated with antiangiogenics targeted agents (sunitinib, sorafenib and bevacizumab). OUTC’s, a French national registry, collects data about the use of off-label targeted therapy in sarcoma.
Eight males and one woman were included, with median age at diagnosis of 27.3 years (range from 9 to 48 years). They received a mean 3 lines (2–5) of treatment before antiangiogenic agent initiation. Six patients received sunitinib, two received sorafenib and one bevacizumab. Median progression free survival was 3.1 months (range 2–5.5 months) and best response observed was 5.5 months stable disease. Most patients had manageable low-grade toxicities, mainly fatigue, abdominal pain and skin toxicity.
Despite very limited activity of antiangiogenics in our study, prospective collection of cases of these rare tumors together with molecular data should guide therapeutic decision and enhance outcome.
Desmoplastic small round cell tumor (DSRCT) was first described in 1989 by Gerald and Rosai , as a tumor made of small round blue cells separated by abundant desmoplastic stroma. Fewer than 800 cases have been reported in the literature. DSRCT is therefore rare. DSRCT is an aggressive tumor, which mainly affects teenagers and young adults, predominantly males (sex ratio 4:1 to 9:1) with a peak incidence in the third decade of life.
On histological examination, tumor cells may display epithelial, mesenchymal and neuronal markers . DSRCT is associated with a unique translocation t(11:22) (p13, q12) resulting in a fusion of the EWSR1 and the Wilm’s tumor WT1 genes. The chimeric product acts as an aberrant transcriptional factor and several transcriptional oncogenic targets have been identified including platelet derived growth factor A (PDGFA), insulin like growth factor 1 (IGF1) and WT-1 . However, this has not yet been translated in efficient targeted therapy in this disease.
DRSCT typically involves the abdominal and peritoneal cavity, but extra-peritoneal organs may be affected [4,5,6]. Retroperitoneal lymph nodes, liver or lung metastases occur up to 50% cases at diagnosis . There is no validated disease staging system, although the peritoneal cancer index (PCI) may be used for peritoneal disease  and Hayes-Jordan et al. have proposed a staging system specific to DSRCT .
With only one large case series described, the best therapeutic strategy remains unclear. DSRCT has a poor prognosis with a median OS of 25 months  and a 29 and 18% 3 and 5-years survival rate [10, 11]. A few small series suggest that intensive chemotherapy followed by extensive debulking surgery and abdominal radiation may improve the outcome of patients with operable disease [7, 12, 13]. Polychemotherapy schedule using alkylating agents and anthracyclins such as P6 protocol (cyclophosphamide, doxorubicin, vincristine, ifosfamide, etoposide, irinotecan and platinum alternating schedule) is associated with better outcome. A few centers have advocated the use of hyperthermic intraperitoneal chemotherapy (HIPEC) but, in the absence of randomized study, it is difficult to decipher the actual treatment effect from a selection bias in these series [14, 15]. Whole abdominal pelvic radiation therapy (WAP RT) and increasing development of intensity modulated radiation therapy were also described as a part of the adjuvant treatment [16, 17].
Overall, despite multimodal strategy, long term survivor rate remains low, with fewer than 20% of patients achieving 5-year survival . Tumor recurrence and progression is the rule. After first line treatment, several cytotoxic agents have been studied, alone or in combination, including vinorelbine and cyclophosphamide , irinotecan , trabectedin [20, 21]. However, response rates are low and only partial responses are described and response duration remains short, range from 3 to 9 months.
Recently, there has been interest in the potential role of antiangiogenic tyrosine kinase inhibitors. Indeed, expression of EWS-WT1 induces PDGFA, a potent mitogen for fibroblast and endothelial cells. Particularly, PDGFA blockade may be interesting in DSRCT because of a profuse stromal reaction and neoangiogenesis surrounding tumor cells . Thus, tyrosine kinase PDGFA receptor (PDGFRA) inhibitors such as imatinib and multikinase inhibitors, sunitinib and pazopanib, have been tested in DSRCT [22,23,24]. Our study reports nine cases of progressive DSRCT treated with antiangiogenic targeted agents, and registered in the national registry “OUTC’s” dedicated to the use of off-labeled targeted therapy in sarcoma.
Patients and methods
OUTC’s registry (Observatoire de l’Utilisation des Thérapies Ciblées dans le Sarcome) aims to collect, in a prospective manner, all medical data regarding the use of off-label targeted therapies in sarcoma to assess their efficacy and toxicity profile . Off-label prescription is authorized in France for rare disease under control of experts, based on published data reporting potential activity.
Patients with confirmed progressive DSRCT, not amendable to curative treatment, were included. As our study was not interventional, written consent was not required. However, patients were informed and gave oral consent for data collection and use of clinical data for research purposes. All patients received a detailed information letter and had the opportunity to withdraw their consent at any time. Children could be included with their parent’s consent. Progressive DSRCT was confirmed, in seven of our nine cases, by a systematic pathological review as part of two databases dedicated to collection and management of cases of soft tissue and visceral sarcomas (REePS: https://rreps.sarcomabcb.org/; and European Conticabase: https://conticabase.sarcomabcb.org/). All data were collected by the coordination center (Centre Léon Bérard, Lyon) after approval of the Centre Léon Bérard Clinical Trial Review Committee and two French data protection authorities (CCTIRS: Additional file 1; and CNIL: Additional file 2). Five university hospitals (all members of the GSF-GETO) participated and included all consecutive patients. Once a patient was registered, follow-up was established every 2 months by the coordination center.
The primary objective was to describe the efficacy of antiangiogenics agents in advanced DSRCT. Efficacy endpoints included response rate [i.e. partial and complete response (PR, CR)], according to RECIST criteria, disease control rate (i.e. rate of CR, PR and stable disease (SD) as best overall response) and progression free survival (PFS) under treatment. Secondary objective included characterization of safety profile.
Descriptive analysis was done using median values and range. PFS was defined as the time from start of AAT until progressive disease according to RECIST, or death. Safety evaluation was based on the frequency and severity of toxicities, graded according to the common terminology criteria for adverse events.
From July 2002 to July 2013, 9 patients in 5 institutions were registered and received antiangiogenics targeted therapies (AAT) for advanced desmoplastic tumors. Patient and tumor characteristics, tumor staging and treatment are summarized in Table 1. There were 8 males. The median age at diagnosis was 27.3 years (range 9–48 years) and two patients were under the age of 18 years at diagnosis. Most patients had metastatic disease at diagnosis and have received multimodal treatment. Seven patients had surgical debulking of the primary tumor. First-line chemotherapy was generally based on anthracycline, ifosfamide and methotrexate. Three patients received radiotherapy as part of first line treatment. Median PFS after first line treatment was 19.5 months (range 6–47 months). Relapsed and progressive disease was treated with various chemotherapy regimens containing platinum, gemcitabine, irinotecan, temozolomide or trabectedine. Overall, for relapsed disease, complete response was observed for 2 first relapsed patients, with HIPEC and FOLFIRI regimen for one and etoposide, carboplatine, thiotepa and busulfan for the other one (PFS 17 and 12 months respectively). For the other patients short disease stabilization was the best response obtained with these second line regimens. Overall, second line treatment was associated with a median PFS of 10.5 months (range 2–17 months).
The median time from diagnosis to AAT was 3.6 years (range 10–78 months). Two patients received others targeted therapies, in 3rd line treatment, as part of a clinical trial (Ridaforolimus, mTOR inhibitor/SUCCEED trial NCT00538239, Dalotuzumab, IGFR1 inhibitor/DALORI trial) before they both received sunitinib. The median number of previous chemotherapy treatments before AAT was 3 (range 2–5). All patients had confirmed progressive disease at the time of initiation of AAT. In seven cases the decision to use off-label AAT was made after discussion in a multidisciplinary meeting. Six patients received sunitinib, two patients received sorafenib and one received bevacizumab. All treatments are summarized in Table 2.
Efficacy data were collected every 2 months. Individual responses to previous treatments and AAT are detailed in Table 2. The median PFS was 3.1 months for patients who received sunitinib. Overall, for the nine patients treated with AAT, the disease control rate at 2 months was 66.7% and PFS was also 3.1 months. The patient treated with bevacizumab died from progressive disease at 2 months and the patients treated with sorafenib had progressive disease at 4 months. Overall, for these nine patients, the best response had been stable disease.
The main toxicities are presented in Table 3. Among the six patients treated with sunitinib, gastro-intestinal toxicity and fatigue were the most common adverse events (AEs) (n = 4). One patient had grade 3 hepatitis, but otherwise, most AEs were low grade and none required interruption of sunitinib. One patient treated with sorafenib had grade 1 skin toxicity and grade 2 cough. The other patient treated with sorafenib had grade 3 abdominal pain that required cessation of treatment. Overall, the toxicity profile seen with these agents was similar to that observed in others studies . There were no grade IV adverse events and no toxic deaths occurred during follow-up.
Relapsed and refractory DSRCT remains associated with very poor prognosis. As noted above, multimodal therapy that combines polychemotherapy, debulking surgery and radiotherapy is associated with better outcome than less comprehensive treatment [7, 12].
In our case series, clinical patients characteristics are comparable to those of previous series. Seven of our nine patients had debulking surgery even in presence of metastatic disease at diagnosis. First-line chemotherapy was based on anthracyclines, ifosfamide and etoposide using regimens adapted from the P6 protocol. These approaches are similar than those used in the most studies reported to date and are considered as standard care. The median PFS following first-line treatment was 19.5 months, which is comparable with PFS reported in the literature [11, 27].
There is no standard approach beyond first line, and patients received in most cases chemotherapy and salvage surgery when feasible. Gemcitabine, temozolamide, irinotecan and trabectedine were the main cytotoxic agents used. Overall, second line treatment was associated with a median PFS of 10.5 months (range 2–17 months). The only one patient who was treated with sunitinib monotherapy had a PFS of only 2 months. These data suggest that, if performance status allows, treatment for relapsed disease should again be based on combination chemotherapy.
Recent data suggest the interest of novel targeted therapy, against several biological processes involved in DSRCT pathogenesis, to treat recurrent diseases. Based on Ewing sarcoma model and EWS-Fli translocation, leading to dysregulation of insulin growth factor 1 (IGF1) receptor and dependence on IGF1 [28, 29], humanized monoclonal antagonist IGF1 receptor (IGF1R) antibodies have been developed [30, 31]. As part of clinical trial, one of our patients received the IGF1R antibody dalotuzumab, with a low PFS.
The modest efficacy of these signaling inhibitors and the development of resistance provide a rationale for the use of antiangiogenic multi-targeted kinase inhibitors. Only a few AATs have been tested in patients with relapsed and refractory DSRCT. Imatinib was used in a phase II study for two patients with DSRCT expressing KIT and/or PDGFRα with very limited response . This may be explained by the fact that KIT expression probably leads to tumorigenicity as a spectrum, with more reliance on other kinase pathways, and may be targeted by other tyrosine kinase small molecules inhibitors . Sunitinib is a multi-targeted agent that potently inhibits PDGFR, KIT, FLT3, CSF-1 and RET, as well as vascular endothelial growth factor (VEGF) receptor tyrosine kinases. It targets multiple signaling pathways in tumor, stromal, and endothelial compartments that are relevant to DSRCT . Six of our patients received sunitinib as AAT for progressive disease with a median PFS of 3.1 months. Thus, sunitinib activity seems to be comparable to recent eight cases reported by Italiano et al. with median PFS of 2.6 months .
Overall, our results are similar to those described in the other retrospective analyses of monochemotherapy and most AAT for progressive DSRCT (Table 4). Efficacy was modest and the best response obtained was stable disease. However, a retrospective study of pazopanib in nine DSRCT cases reported promising results with a 9.2 months PFS . Such as sunitinib, pazopanib is an orally available inhibitor of the tyrosine kinases of several factors including the vascular endothelial growth factor receptors (VEGFR) 1–3, c-KIT, and the platelet-derived growth factor receptors (PDGFR) alpha and beta, and has been approved for advanced soft tissue sarcoma.
This cohort, although small and retrospective, confirms the safety of AATs. AEs were mostly low grade and manageable, similar to those previously reported in other series.
Moreover, recent data on olaratumab, a recombinant human IgG1 monoclonal antibody that specifically binds PDGFRA and receptor activation, and its FDA approval, may significantly improve outcome of patients with soft tissue sarcoma. In this study, only one patient had an undifferentiated round cell sarcoma negative for EWS in olaratumab treatment arm .
OUTC’S program allows the collection of data on the off-label use of TTs in rare tumors such as DSRCT. This is especially useful since such patients are generally ineligible for clinical trials. Moreover new treatment development in DSRCT remains poor. Despite negative results, this study suggests that AAT with sunitinb, sorafenib or bevacizumab monotherapy doesn’t seem to be the best approach to treat progressive DSRCT. Identification of molecular pathways and specific mutations involved in DSRCT pathogenesis may allow the development of new targeted and combination treatments to improve response rate and survival in relapsed and progressive DSRCT. Thus, IGFR1 inhibitors and multi-targeted kinase inhibitors may be another treatment strategy, probably in combination with chemotherapy. Prospective collection of cases of these rare tumors treated with targeted therapies together with increased molecular data understanding should improve therapeutic decision and enhance outcome.
desmoplastic small round cell tumor
platelet derived growth factor A
platelet derived growth factor receptor A
insulin like growth factor 1
- WAP RT:
whole abdominal pelvic radiation therapy
hyperthermic intraperitoneal chemotherapy
anti-angiogenic targeted therapy
Gerald WL, Rosai J. Case 2 desmoplastic small cell tumor with divergent differentiation. Pediatr Pathol. 1989;9:177–83.
Zhang J, Dalton J, Fuller C. Epithelial marker-negative desmoplastic small round cell tumor with atypical morphology: definitive classification by fluorescence in situ hybridization. Arch Pathol Lab Med. 2007;131:646–9.
Gerald WL, Haber DA. The EWS-WT1 gene fusion in desmoplastic small round cell tumor. Semin Cancer Biol. 2005;15:197–205.
Tison V, Cerasoli S, Morigi F, Ladanyi M, Gerald WL, Rosai J. Intracranial desmoplastic small-cell tumor: report of a case. Am J Surg Pathol. 1996;20:112–7.
Yue X, Wang JZ, Tian Y, Wang KJ. Paratesticular desmoplastic small round cell tumor with metastasis: a report of two cases. Kaohsiung J Med Sci. 2014;30:104–5.
Nakayama J, Nassau S, Atkins K, Modesitt SC. Desmoplastic small round cell tumor of the ovary: a rare but devastating disease in young women. Gynecol Oncol Case Rep. 2014;7:16–8.
Honoré C, Amroun K, Vilcot L, Mir O, Domont J, Terrier P, Le Cesne A, Le Péchoux C, Bonvalot S. Abdominal desmoplastic small round cell tumor: multimodal treatment combining chemotherapy, surgery, and radiotherapy is the best option. Ann Surg Oncol. 2015;22:1073–9.
Dufresne A, Cassier P, Couraud L, Marec-Bérard P, Meeus P, Alberti L, Blay JY. Desmoplastic small round cell tumor: current management and recent findings. Sarcoma. 2012;2012:714986.
Hayes-Jordan A, Green H, Fitzgerald N, Xiao L, Anderson P. Novel treatment for desmoplastic small round cell tumor: hyperthermic intraperitoneal perfusion. J Pediatr Surg. 2010;45:1000–6.
Mingo L, Seguel F, Rollán V. Intraabdominal desmoplastic small round cell tumour. Pediatr Surg Int. 2005;21:279–81.
Kushner BH, LaQuaglia MP, Wollner N, Meyers PA, Lindsley KL, Ghavimi F, Merchant TE, Boulad F, Cheung NK, Bonilla MA, et al. Desmoplastic small round-cell tumor: prolonged progression-free survival with aggressive multimodality therapy. J Clin Oncol. 1996;14:1526–31.
Lal DR, Su WT, Wolden SL, Loh KC, Modak S, La Quaglia MP. Results of multimodal treatment for desmoplastic small round cell tumors. J Pediatr Surg. 2005;40:251–5.
Shoushtari AG. MM. Predictors of overall survival in patients diagnosed with desmoplastic small round cell tumor (DSRCT). J Clin Oncol. 2014;32(5):2014.
Hayes-Jordan A, Green HL, Lin H, Owusu-Agyemang P, Fitzgerald N, Arunkumar R, Mejia R, Okhuysen-Cawley R, Mauricio R, Fournier K, et al. Complete cytoreduction and HIPEC improves survival in desmoplastic small round cell tumor. Ann Surg Oncol. 2014;21:220–4.
Bakrin N, Bereder JM, Decullier E, Classe JM, Msika S, Lorimier G, Abboud K, Meeus P, Ferron G, Quenet F, et al. Peritoneal carcinomatosis treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) for advanced ovarian carcinoma: a French multicentre retrospective cohort study of 566 patients. Eur J Surg Oncol. 2013;39:1435–43.
Pinnix CC, Fontanilla HP, Hayes-Jordan A, Subbiah V, Bilton SD, Chang EL, Grosshans DR, McAleer MF, Sulman EP, Woo SY, et al. Whole abdominopelvic intensity-modulated radiation therapy for desmoplastic small round cell tumor after surgery. Int J Radiat Oncol Biol Phys. 2012;83:317–26.
Desai NB, Stein NF, LaQuaglia MP, Alektiar KM, Kushner BH, Modak S, Magnan HM, Goodman K, Wolden SL. Reduced toxicity with intensity modulated radiation therapy (IMRT) for desmoplastic small round cell tumor (DSRCT): an update on the whole abdominopelvic radiation therapy (WAP-RT) experience. Int J Radiat Oncol Biol Phys. 2013;85:e67–72.
Ferrari A, Grosso F, Stacchiotti S, Meazza C, Zaffignani E, Marchianò A, Casanova M. Response to vinorelbine and low-dose cyclophosphamide chemotherapy in two patients with desmoplastic small round cell tumor. Pediatr Blood Cancer. 2007;49:864–6.
Bisogno G, Riccardi R, Scagnellato A, Arcamone G, Miglionico L, Carli M. No effect of irinotecan in patients with resistant desmoplastic small round cell tumor. Pediatr Blood Cancer. 2010;54:182–3.
López-González A, Cantos B, Tejerina E, Provencio M. Activity of trabectidin in desmoplastic small round cell tumor. Med Oncol. 2011;28(Suppl 1):S644–6.
Frezza AM, Whelan JS, Dileo P. Trabectedin for desmoplastic small round cell tumours: a possible treatment option? Clin Sarcoma Res. 2014;4:3.
Chao J, Budd GT, Chu P, Frankel P, Garcia D, Junqueira M, Loera S, Somlo G, Sato J, Chow WA. Phase II clinical trial of imatinib mesylate in therapy of KIT and/or PDGFRalpha-expressing Ewing sarcoma family of tumors and desmoplastic small round cell tumors. Anticancer Res. 2010;30:547–52.
Italiano A, Kind M, Cioffi A, Maki RG, Bui B. Clinical activity of sunitinib in patients with advanced desmoplastic round cell tumor: a case series. Target Oncol. 2013;8:211–3.
Frezza AM, Benson C, Judson IR, Litiere S, Marreaud S, Sleijfer S, Blay JY, Dewji R, Fisher C, van der Graaf W, Hayward L. Pazopanib in advanced desmoplastic small round cell tumours: a multi-institutional experience. Clin Sarcoma Res. 2014;4:7.
Eberst L, Cropet C, Le Cesne A, Pautier P, Penel N, Adenis A, Chevreau C, Bay JO, Collard O, Cupissol D, et al. The off-label use of targeted therapies in sarcomas: the OUTC’S program. BMC Cancer. 2014;14:870.
Ravaud A, Motzer RJ, Pandha HS, George DJ, Pantuck AJ, Patel A, Chang YH, Escudier B, Donskov F, Magheli A, et al. Adjuvant sunitinib in high-risk renal-cell carcinoma after nephrectomy. N Engl J Med. 2016;375:2246–54.
Whelan J, Khan A, Sharma A, Rothermundt C, Dileo P, Michelagnoli M, Seddon B, Strausss S. Interval compressed vincristine, doxorubicin, cyclophosphamide alternating with ifosfamide, etoposide in patients with advanced Ewing’s and other small round cell sarcomas. Clin Sarcoma Res. 2012;2:12.
Karnieli E, Werner H, Rauscher FJ, Benjamin LE, LeRoith D. The IGF-I receptor gene promoter is a molecular target for the Ewing’s sarcoma-Wilms’ tumor 1 fusion protein. J Biol Chem. 1996;271:19304–9.
Finkeltov I, Kuhn S, Glaser T, Idelman G, Wright JJ, Roberts CT, Werner H. Transcriptional regulation of IGF-I receptor gene expression by novel isoforms of the EWS-WT1 fusion protein. Oncogene. 2002;21:1890–8.
Tap WD, Demetri G, Barnette P, Desai J, Kavan P, Tozer R, Benedetto PW, Friberg G, Deng H, McCaffery I, et al. Phase II study of ganitumab, a fully human anti-type-1 insulin-like growth factor receptor antibody, in patients with metastatic Ewing family tumors or desmoplastic small round cell tumors. J Clin Oncol. 2012;30:1849–56.
Naing A, LoRusso P, Fu S, Hong DS, Anderson P, Benjamin RS, Ludwig J, Chen HX, Doyle LA, Kurzrock R. Insulin growth factor-receptor (IGF-1R) antibody cixutumumab combined with the mTOR inhibitor temsirolimus in patients with refractory Ewing’s sarcoma family tumors. Clin Cancer Res. 2012;18:2625–31.
Chow LQ, Eckhardt SG. Sunitinib: from rational design to clinical efficacy. J Clin Oncol. 2007;25:884–96.
Thijs AM, van der Graaf WTA, van Herpen CML. Temsirolimus for metastatic desmoplastic small round cell tumor. Pediatr Blood Cancer 2010;55(7):1431–2.
Tap WD, Jones RL, Van Tine BA, Chmielowski B, Elias AD, Adkins D, Agulnik M, Cooney MM, Livingston MB, Pennock G, et al. Olaratumab and doxorubicin versus doxorubicin alone for treatment of soft-tissue sarcoma: an open-label phase 1b and randomised phase 2 trial. Lancet. 2016;388:488–97.
Study conception and design: JYB, IRC. Acquisition of data: CB, JYB, EP, PC, JF, CG, ALC, PMB, IRC, CC. Data management: LC, MG. Analysis and interpretation of data: SB, CC IRC. Drafting and revision of the manuscript: SB, CC, IRC, PMB. Obtained funding: IRC. Administrative, technical and material support: IRC. Study supervision: CC, IRC. All authors read and approved the final manuscript.
The authors would like to acknowledge the DAM’s association and the Ain department’s league for financial support, Laure Chevallier and Muriel Rogasick for OUTC’s data management.
Dr. LE CESNE declares honoraria from Pharmamar, Novartis-GSK, Lilly and Pfizer. All remaining authors declare that they have no competing interests. Dr. MAREC-BERARD reported receiving travel stipends from Novartis, Pharmamar SARL, ROCHE. All remaining authors declare that they have no competing interests.
Availability of data and materials
The datasets generated and analysed during the current study are available in the coordination center (Centre Leon Berard).
Ethics approval and consent to participate
The study was approved by the two committees: CNIL (Commission Nationale d’Information et Libertés: French national agency regulating data protection) and CCTIRS (Comité Consultatif sur le traitement de l’information en matière de recherche dans le domaine de la santé) (Additional file 1). The study had to be approved by the Multidisciplinary Sarcoma Board (MSB) of all participating centers according to the French Cancer Plan recommendations. As the study was not interventional, formal written consent was not required by French law. However, patients were informed and gave oral consent for data collection and use of clinical data for research purposes. Children could be included with their parents’ consent. All patients received a detailed information letter and had the opportunity to withdraw their consent at any time.
This study was financially supported by Dam’s (Détecter Alerter Mobiliser sarcomes) patients advocacy group and the Ain department league.
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
CCTIRS (Comité Consultatif sur le traitement de l’information en matière de recherché dans le domaine de la santé) approved the relevance of the personal name specific data with regard to the objective of the research.
CNIL (Comité National d’Information et Libertés) French committee in charge of watching that the computing is in the service of the citizen and that it strikes a blow neither at the human identity, nor at the human rights, nor at the private life, nor at the personal or public freedoms.
About this article
Cite this article
Bétrian, S., Bergeron, C., Blay, J. et al. Antiangiogenic effects in patients with progressive desmoplastic small round cell tumor: data from the French national registry dedicated to the use of off-labeled targeted therapy in sarcoma (OUTC’s). Clin Sarcoma Res 7, 10 (2017). https://doi.org/10.1186/s13569-017-0076-4
- Desmoplastic small round cell tumor
- Chemotherapy treatment