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  1. Soft tissue and bone sarcoma represent a broad spectrum of different pathology and genetic variance. Current chemotherapy regimens are derived from randomised trials and represent empirical treatment. Chemosen...

    Authors: Nicholas Calvert, Jiansha Wu, Sophie Sneddon, Jennifer Woodhouse, Richard Carey-Smith, David Wood and Evan Ingley

    Citation: Clinical Sarcoma Research 2018 8:4

    Content type: Research

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  2. Retroperitoneal sarcomas (RPS) should be surgically managed in specialized sarcoma centers. However, it is not clearly demonstrated if clinical outcome is more influenced by Center Case Volume (CCV) or by Surg...

    Authors: Sergio Sandrucci, Agostino Ponzetti, Claudio Gianotti, Baudolino Mussa, Patrizia Lista, Giovanni Grignani, Marinella Mistrangelo, Oscar Bertetto, Daniela Di Cuonzo and Giovannino Ciccone

    Citation: Clinical Sarcoma Research 2018 8:3

    Content type: Research

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  3. Papillary intralymphatic angioendothelioma (PILA) is a locally aggressive, rarely metastasizing vascular tumor, generally occurring in the soft tissues, with less than 40 cases described in the literature and ...

    Authors: Marco Gambarotti, Alberto Righi, Marta Sbaraglia, Giuseppe Bianchi, Piero Picci, Daniel Vanel and Angelo Paolo Dei Tos

    Citation: Clinical Sarcoma Research 2018 8:1

    Content type: Case report

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  4. Ossifying fibromyxoid tumor (OFMT) is a rare soft tissue neoplasm of uncertain lineage and intermediate biological potential. It is more common in middle-aged men, usually arising from the deep tissues of the ...

    Authors: Salvatore Provenzano, Alessandra Raimondi, Rossella M. Bertulli, Vittoria Colia, Salvatore L. Renne, Paola Collini, Gianpaolo Dagrada, Dario Callegaro, Marco Fiore, Francesca G. Greco and Paolo G. Casali

    Citation: Clinical Sarcoma Research 2017 7:20

    Content type: Case report

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  5. Treatment of giant cell tumour of bone (GCTB) of the distal radius/ulna poses a surgical challenge, as complex reconstructive surgery may be required. This study evaluates the clinical, radiological and pathol...

    Authors: Catherine L. McCarthy, Christopher L. M. H. Gibbons, Kevin M. Bradley, A. Bass Hassan, Henk Giele and Nicholas A. Athanasou

    Citation: Clinical Sarcoma Research 2017 7:19

    Content type: Research

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  6. Since treatment patterns in metastatic soft tissue sarcoma (mSTS) have not been studied subsequent to US approval of pazopanib in 2012, this study sought to examine mSTS treatment patterns by line of therapy, ...

    Authors: Victor M. Villalobos, Stacey DaCosta Byfield, Sameer R. Ghate and Oluwakayode Adejoro

    Citation: Clinical Sarcoma Research 2017 7:18

    Content type: Research

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  7. VS38c is a monoclonal antibody that recognises a rough endoplasmic reticulum (rER) intracellular antigen termed cytoskeleton-linking membrane protein 63. rER is typically found in viable tumour cells and is ab...

    Authors: E. S. Hookway, Z. Orosz, Y. Uchihara, A. Grigoriadis, A. B. Hassan, U. Oppermann and N. A. Athanasou

    Citation: Clinical Sarcoma Research 2017 7:17

    Content type: Research

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  8. We report on the activity of anthracycline-based and high-dose prolonged-infusion ifosfamide chemotherapy in a retrospective series of patients affected by advanced myxofibrosarcoma treated at Istituto Naziona...

    Authors: Vittoria Colia, Marco Fiore, Salvatore Provenzano, Elena Fumagalli, Rossella Bertulli, Carlo Morosi, Angelo P. Dei Tos, Marta Barisella, Alessandro Gronchi, Paolo G. Casali and Roberta Sanfilippo

    Citation: Clinical Sarcoma Research 2017 7:16

    Content type: Research

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  9. Radiation induced angiosarcoma (RIAS) of the breast is a rare and aggressive complication of radiotherapy. Due to the rarity of this disease, much of the evidence for its management is based on case reports or...

    Authors: R. B. Cohen-Hallaleh, H. G. Smith, R. C. Smith, G. F. Stamp, O. Al-Muderis, K. Thway, A. Miah, K. Khabra, I. Judson, R. Jones, C. Benson and A. J. Hayes

    Citation: Clinical Sarcoma Research 2017 7:15

    Content type: Research

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  10. Primary pulmonary artery sarcomas are rare malignant vascular tumors and carry a very poor prognosis. Due to overlapping clinical and radiological features, the differentiation between pulmonary artery thrombo...

    Authors: Abhishek Mahajan, Bharat Rekhi, Siddhartha Laskar, Jyoti Bajpai, Lekshmy Jayasree and Meenakshi H. Thakur

    Citation: Clinical Sarcoma Research 2017 7:13

    Content type: Case report

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  11. PRAME (preferentially expressed antigen in melanoma), a member of the cancer-testis antigen family, has been shown to have increased expression in solid tumors, including sarcoma, and PRAME-specific therapies ...

    Authors: Jason Roszik, Wei-Lien Wang, John A. Livingston, Christina L. Roland, Vinod Ravi, Cassian Yee, Patrick Hwu, Andrew Futreal, Alexander J. Lazar, Shreyaskumar R. Patel and Anthony P. Conley

    Citation: Clinical Sarcoma Research 2017 7:11

    Content type: Research

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  12. Leiomyosarcoma of the head and neck is a rare cancer with high local aggressiveness. Radical surgery and adjuvant treatment offer the best chance for cure, nonetheless 5-years recurrence rate remains high. Des...

    Authors: Enrico Pinotti, Marta Sandini, Simone Famularo, Marta Jaconi, Fabrizio Romano, Luca Nespoli and Luca Gianotti

    Citation: Clinical Sarcoma Research 2017 7:12

    Content type: Case Report

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  13. Desmoplastic small round cell tumor (DSRCT) is a very rare mesenchymal tumor that mainly affects teenagers and young adults with a mean age at diagnosis around 20–25 years. Although initial management still ne...

    Authors: Sarah Bétrian, Christophe Bergeron, Jean-Yves Blay, Emmanuelle Bompas, Philippe A. Cassier, Laure Chevallier, Jérome Fayette, Magali Girodet, Cécile Guillemet, Axel Le Cesne, Perrine Marec-Berard, Isabelle Ray-Coquard and Christine Chevreau

    Citation: Clinical Sarcoma Research 2017 7:10

    Content type: Research

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  14. Histone 3.3 (H3.3) hotspot mutations in bone tumors occur in the vast majority of giant cell tumors of bone (GCTBs; 96%), chondroblastomas (95%) and in a few cases of osteosarcomas. However, clinical presentat...

    Authors: Christian Koelsche, Daniel Schrimpf, Lars Tharun, Eva Roth, Dominik Sturm, David T. W. Jones, Eva-Kristin Renker, Martin Sill, Annika Baude, Felix Sahm, David Capper, Melanie Bewerunge-Hudler, Wolfgang Hartmann, Andreas E. Kulozik, Iver Petersen, Uta Flucke…

    Citation: Clinical Sarcoma Research 2017 7:9

    Content type: Research

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  15. Mutations in isocitrate dehydrogenase (IDH)1 or -2 are found in ~50% of conventional central chondrosarcomas and in up to 87% of their assumed benign precursors enchondromas. The mutant enzyme acquires the activi...

    Authors: Arjen H. G. Cleven, Johnny Suijker, Georgios Agrogiannis, Inge H. Briaire-de Bruijn, Norma Frizzell, Attje S. Hoekstra, Pauline M. Wijers-Koster, Anne-Marie Cleton-Jansen and Judith V. M. G. Bovée

    Citation: Clinical Sarcoma Research 2017 7:8

    Content type: Research

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  16. Soft tissue sarcomas (STS) are rare tumours arising in mesenchymal tissues. Gastrointestinal stromal tumour (GIST) is the commonest STS and arises within the wall of the gastrointestinal (GI) tract. While most...

    Authors: Ian Judson, Ramesh Bulusu, Beatrice Seddon, Adam Dangoor, Newton Wong and Satvinder Mudan

    Citation: Clinical Sarcoma Research 2017 7:6

    Content type: Review

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  17. The Italian Sarcoma Group (ISG) is a nonprofit group of professionals established in 1997 aimed to improve the quality of care and promote the independent research in sarcomas. The increased regulatory require...

    Authors: Emanuela Marchesi, Celeste Cagnazzo, Irene Quattrini, Martina Piccinni Leopardi, Chiara Villa, Giovanni Grignani, Lorenzo D’Ambrosio, Silvia Stacchiotti, Paolo Giovanni Casali and Piero Picci

    Citation: Clinical Sarcoma Research 2017 7:4

    Content type: Methodology

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  18. In patients with relapsed osteosarcoma, the surgical excision of all metastases, defined as second complete remission (CR-2), is the factor that mainly influences post-relapse survival (PRS). Currently a valid...

    Authors: Anna Paioli, Michele Rocca, Luca Cevolani, Eugenio Rimondi, Daniel Vanel, Emanuela Palmerini, Marilena Cesari, Alessandra Longhi, Abate Massimo Eraldo, Emanuela Marchesi, Piero Picci and Stefano Ferrari

    Citation: Clinical Sarcoma Research 2017 7:3

    Content type: Research

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    The Erratum to this article has been published in Clinical Sarcoma Research 2017 7:7

  19. Trabectedin has shown efficacy against soft tissue sarcomas (STS) and has manageable toxicity. Trabectedin is administered through central venous access devices (VAD), such as subcutaneous ports with tunneled ...

    Authors: Michiel C. Verboom, Jan Ouwerkerk, Neeltje Steeghs, Jacob Lutjeboer, J. Martijn Kerst, Winette T. A. van der Graaf, Anna K. L. Reyners, Stefan Sleijfer and Hans Gelderblom

    Citation: Clinical Sarcoma Research 2017 7:2

    Content type: Research

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  20. Gastrointestinal stromal tumor (GIST) is the most common mesenchymal neoplasm of the gastrointestinal tract. The main treatment for localized gastrointestinal stromal tumors is surgical resection. Unresectable...

    Authors: L. Gatto, M. Nannini, M. Saponara, V. Di Scioscio, G. Beltramo, G. P. Frezza, G. Ercolani, A. D. Pinna, A. Astolfi, M. Urbini, G. Brandi, G. Biasco and M. A. Pantaleo

    Citation: Clinical Sarcoma Research 2017 7:1

    Content type: Case report

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  21. Manipulation of immune checkpoints such as CTLA4 or PD-1 with targeted antibodies has recently emerged as an effective anticancer strategy in multiple malignancies. Sarcomas are a heterogeneous group of diseas...

    Authors: L. Paoluzzi, A. Cacavio, M. Ghesani, A. Karambelkar, A. Rapkiewicz, J. Weber and G. Rosen

    Citation: Clinical Sarcoma Research 2016 6:24

    Content type: Research

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  22. Extracranial metastasis of malignant meningioma to soft tissues is extremely rare and its clinical, radiological and pathological features are not well-characterised.

    Authors: Catherine McCarthy, Monika Hofer, Marianna Vlychou, Robar Khundkar, Paul Critchley, Simon Cudlip, Olaf Ansorge and Nick A. Athanasou

    Citation: Clinical Sarcoma Research 2016 6:23

    Content type: Case report

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  23. Imatinib mesylate (IM) is the preferred treatment for the majority of patients with metastatic gastrointestinal stromal tumour (GIST). Low trough IM concentration (Cmin) values have been associated with poor clin...

    Authors: Ivar Hompland, Øyvind Sverre Bruland, Kumari Ubhayasekhera, Jonas Bergquist and Kjetil Boye

    Citation: Clinical Sarcoma Research 2016 6:21

    Content type: Research

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  24. Aggressive fibromatosis (AF), also known as desmoid tumor, is an uncommon soft tissue neoplasm. AF does not metastasize, but it is locally invasive and its propensity for recurrence after conservative resectio...

    Authors: Gulcan Bulut, Anil Ozluk, Atike Pınar Erdogan, Ruchan Uslu, Nevra Elmas and Burcak Karaca

    Citation: Clinical Sarcoma Research 2016 6:22

    Content type: Case report

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  25. Soft tissue sarcomas (STS) are rare tumours arising in mesenchymal tissues, and can occur almost anywhere in the body. Their rarity, and the heterogeneity of subtype and location means that developing evidence...

    Authors: Adam Dangoor, Beatrice Seddon, Craig Gerrand, Robert Grimer, Jeremy Whelan and Ian Judson

    Citation: Clinical Sarcoma Research 2016 6:20

    Content type: Review

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  26. Chordomas are rare malignant tumours of the axial skeleton and skull base supposed to arise from cellular remnants of the notochord. These tumours have the potential to metastasize (30–40 %), usually in the la...

    Authors: Astrid Lipplaa, Sander Dijkstra and Hans Gelderblom

    Citation: Clinical Sarcoma Research 2016 6:19

    Content type: Case report

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  27. The role of age as a prognostic factor has been examined in single institutional studies and in larger data sets from the SEER database, showing a survival advantage for younger versus adult patients with syno...

    Authors: Bernadette Brennan, Charles Stiller, Robert Grimer, Nicola Dennis, John Broggio and Matthew Francis

    Citation: Clinical Sarcoma Research 2016 6:18

    Content type: Research

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  28. Previous studies on high grade sarcomas using mass spectrometry imaging showed proteasome activator complex subunit 1 (PSME1) to be associated with poor survival in soft tissue sarcoma patients. PSME1 is invol...

    Authors: Sha Lou, Arjen H. G. Cleven, Benjamin Balluff, Marieke de Graaff, Marie Kostine, Inge Briaire-de Bruijn, Liam A. McDonnell and Judith V. M. G. Bovée

    Citation: Clinical Sarcoma Research 2016 6:17

    Content type: Research

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  29. Denosumab is a monoclonal antibody to RANK ligand approved for use in giant cell tumour (GCT) of bone. Due to its efficacy, Denosumab is recommended as the first option in inoperable or metastatic GCT. Denosum...

    Authors: Czar Louie Gaston, Robert J. Grimer, Michael Parry, Silvia Stacchiotti, Angelo Paolo Dei Tos, Hans Gelderblom, Stefano Ferrari, Giacomo G. Baldi, Robin L. Jones, Sant Chawla, Paolo Casali, Axel LeCesne, Jean-Yves Blay, Sander P. D. Dijkstra, David M. Thomas and Piotr Rutkowski

    Citation: Clinical Sarcoma Research 2016 6:15

    Content type: Review

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  30. Solitary fibrous tumour (SFT) is a rare soft tissue sarcoma with a low metastatic potential. A higher metastatic rate is observed in the high-grade/dedifferentiated variant. The most common expected site of di...

    Authors: Vittoria Colia, Salvatore Provenzano, Carlo Morosi, Paola Collini, Salvatore Lorenzo Renne, Paolo G. Dagrada, Claudia Sangalli, Angelo Paolo Dei Tos, Andrea Marrari, Paolo G. Casali and Silvia Stacchiotti

    Citation: Clinical Sarcoma Research 2016 6:16

    Content type: Case Report

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  31. A chronic inflammatory cell infiltrate is commonly seen in response to primary malignant tumours of bone. This is known to contain tumour-associated macrophages (TAMs) and lymphocytes; dendritic cells (DCs) an...

    Authors: Y. Inagaki, E. Hookway, K. A. Williams, A. B. Hassan, U. Oppermann, Y. Tanaka, E. Soilleux and N. A. Athanasou

    Citation: Clinical Sarcoma Research 2016 6:13

    Content type: Research

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  32. Advances in treatment of sarcoma patients has prolonged survival but has led to increased disease- or treatment-related complications resulting in greater number of admissions to the intensive care unit (ICU)....

    Authors: Rohan Gupta, Neda Heshami, Chouhan Jay, Naveen Ramesh, Juhee Song, Xiudong Lei, Erfe Jean Rose, Kristen Carter, Dejka M. Araujo, Robert S. Benjamin, Shreyaskumar Patel, Joseph L. Nates and Vinod Ravi

    Citation: Clinical Sarcoma Research 2016 6:12

    Content type: Research

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  33. There is a paucity of data on the current management of patients with advanced soft tissue sarcoma (STS) in the Australian health care setting. This study utilised the Australian sarcoma database to evaluate t...

    Authors: Susie Bae, Philip Crowe, Raghu Gowda, Warren Joubert, Richard Carey-Smith, Paul Stalley and Jayesh Desai

    Citation: Clinical Sarcoma Research 2016 6:11

    Content type: Research

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  34. Most GISTs have mutations in KIT or PDGFRA. Patients with advanced GIST with KIT exon 9, PDGFRA mutation or WT for KIT and PDGFRA have a worse progression-free survival (PFS) compared to patients with KIT exon...

    Authors: Joan Maurel, Antonio López-Pousa, Silvia Calabuig, Silvia Bagué, Xavier Garcia del Muro, Xavier Sanjuan, Jordi Rubió-Casadevall, Miriam Cuatrecasas, Javier Martinez-Trufero, Carlos Horndler, Joaquin Fra, Claudia Valverde, Andrés Redondo, Andrés Poveda, Isabel Sevilla, Nuria Lainez…

    Citation: Clinical Sarcoma Research 2016 6:10

    Content type: Research

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  35. Sarcomas are a heterogeneous group of mesenchymal malignancies. In recent years, studies have demonstrated that inhibition of angiogenic pathways or disruption of established vasculature can attenuate the grow...

    Authors: Kieuhoa T. Vo, Katherine K. Matthay and Steven G. DuBois

    Citation: Clinical Sarcoma Research 2016 6:9

    Content type: Review

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  36. Angiosarcoma is a rare subgroup of soft tissue sarcomas associated with poor prognosis, but paclitaxel has been shown to be active in pretreated metastatic disease. We investigated the efficacy and safety of w...

    Authors: Seonggyu Byeon, Haa-Na Song, Hee Kyung Kim, Jun Soo Ham, Su Jin Lee, Jeeyun Lee and Se Hoon Park

    Citation: Clinical Sarcoma Research 2016 6:8

    Content type: Research

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  37. This document is an update of the British Sarcoma Group guidelines published in 2010. The aim is to provide a reference standard for the clinical care of patients in the UK with bone sarcomas. Recent recommend...

    Authors: Craig Gerrand, Nick Athanasou, Bernadette Brennan, Robert Grimer, Ian Judson, Bruce Morland, David Peake, Beatrice Seddon and Jeremy Whelan

    Citation: Clinical Sarcoma Research 2016 6:7

    Content type: Review

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  38. Zoledronic acid (ZA) is a third-generation bisphosphonate in widespread clinical use to reduce pain and skeletal events in patients from a variety of malignancies with bone metastases. Pre-clinical studies ind...

    Authors: Robert M. Conry, Michael G. Rodriguez and Joseph G. Pressey

    Citation: Clinical Sarcoma Research 2016 6:6

    Content type: Research

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  39. Kaposi sarcoma is a neoplastic vascular disorder. It usually present on the skin of the upper and lower extremities, rarely in the mucosa of the head and neck. The most common sites reported are within the ora...

    Authors: Karima Mouden, Mouna Khmou, Saida Loughmari, Afaf Semmar, Hanan El Kacemi, Basma El Khannoussi, Tayeb Kebdani, Sanaa Elmajjaoui and Noureddine Benjaafar

    Citation: Clinical Sarcoma Research 2016 6:4

    Content type: Case Report

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  40. This report summarizes the results of the 3rd Joint ENCCA-WP7, EuroSarc, EEC, PROVABES, and EURAMOS European Bone Sarcoma Network Meeting, which was held at the Children’s Cancer Research Institute in Vienna, ...

    Authors: Leo Kager, Jeremy Whelan, Uta Dirksen, Bass Hassan, Jakob Anninga, Lindsey Bennister, Judith V. M. G. Bovée, Bernadette Brennan, Javier M. Broto, Laurence Brugières, Anne-Marie Cleton-Jansen, Christopher Copland, Aurélie Dutour, Franca Fagioli, Stefano Ferrari, Marta Fiocco…

    Citation: Clinical Sarcoma Research 2016 6:3

    Content type: Meeting Report

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  41. Abdominal leiomyosarcoma arising from the mesentery is a rare malignancy. It is an aggressive entity with an overall 5 year survival rate between 20 and 30 %. Surgical resection is the cornerstone of primary t...

    Authors: Mercy Varghese, Oyvind Bruland, Anne Marit Wiedswang, Ingvild Lobmaier, Bård Røsok, Robert S. Benjamin and Kirsten Sundby Hall

    Citation: Clinical Sarcoma Research 2016 6:2

    Content type: Case Report

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  42. Wide local excision with or without radiation therapy (RT) and chemotherapy is widely accepted as appropriate management for soft tissue sarcomas (STS) of the extremity. Although survival and local control rat...

    Authors: Michael Ziegele, David M. King and Manpreet Bedi

    Citation: Clinical Sarcoma Research 2016 6:1

    Content type: Research

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  43. Desmoid tumors are rare benign monoclonal fibroblastic tumors. Their aggressiveness is local with no potential for metastasis or dedifferentiation. Here we report on a 61-year-old patient who presented a local...

    Authors: François Bertucci, Marjorie Faure, Maria-Rosa Ghigna, Bruno Chetaille, Jérôme Guiramand, Laurence Moureau-Zabotto, Anthony Sarran and Delphine Perrot

    Citation: Clinical Sarcoma Research 2015 5:25

    Content type: Case Report

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  44. Rhabdomyosarcoma (RMS), a malignant tumour of mesenchymal origin which can occur at various sites in the body, is one of the most common soft tissue sarcomas in both children and adolescents, but is rare in ad...

    Authors: Panagiotis Karagiannis, Nina Guth, Gabriela B. Thoennissen, Christina Bern, Jan Sperveslage, Ilske Oschlies, Carsten Bokemeyer, Wolfram Klapper, Eva Wardelmann and Nils H. Thoennissen

    Citation: Clinical Sarcoma Research 2015 5:24

    Content type: Case Report

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