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  1. Content type: Methodology

    The Italian Sarcoma Group (ISG) is a nonprofit group of professionals established in 1997 aimed to improve the quality of care and promote the independent research in sarcomas. The increased regulatory require...

    Authors: Emanuela Marchesi, Celeste Cagnazzo, Irene Quattrini, Martina Piccinni Leopardi, Chiara Villa, Giovanni Grignani, Lorenzo D’Ambrosio, Silvia Stacchiotti, Paolo Giovanni Casali and Piero Picci

    Citation: Clinical Sarcoma Research 2017 7:4

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  2. Content type: Research

    In patients with relapsed osteosarcoma, the surgical excision of all metastases, defined as second complete remission (CR-2), is the factor that mainly influences post-relapse survival (PRS). Currently a valid...

    Authors: Anna Paioli, Michele Rocca, Luca Cevolani, Eugenio Rimondi, Daniel Vanel, Emanuela Palmerini, Marilena Cesari, Alessandra Longhi, Abate Massimo Eraldo, Emanuela Marchesi, Piero Picci and Stefano Ferrari

    Citation: Clinical Sarcoma Research 2017 7:3

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    The Erratum to this article has been published in Clinical Sarcoma Research 2017 7:7

  3. Content type: Research

    Trabectedin has shown efficacy against soft tissue sarcomas (STS) and has manageable toxicity. Trabectedin is administered through central venous access devices (VAD), such as subcutaneous ports with tunneled ...

    Authors: Michiel C. Verboom, Jan Ouwerkerk, Neeltje Steeghs, Jacob Lutjeboer, J. Martijn Kerst, Winette T. A. van der Graaf, Anna K. L. Reyners, Stefan Sleijfer and Hans Gelderblom

    Citation: Clinical Sarcoma Research 2017 7:2

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  4. Content type: Case report

    Gastrointestinal stromal tumor (GIST) is the most common mesenchymal neoplasm of the gastrointestinal tract. The main treatment for localized gastrointestinal stromal tumors is surgical resection. Unresectable...

    Authors: L. Gatto, M. Nannini, M. Saponara, V. Di Scioscio, G. Beltramo, G. P. Frezza, G. Ercolani, A. D. Pinna, A. Astolfi, M. Urbini, G. Brandi, G. Biasco and M. A. Pantaleo

    Citation: Clinical Sarcoma Research 2017 7:1

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  5. Content type: Research

    Manipulation of immune checkpoints such as CTLA4 or PD-1 with targeted antibodies has recently emerged as an effective anticancer strategy in multiple malignancies. Sarcomas are a heterogeneous group of diseas...

    Authors: L. Paoluzzi, A. Cacavio, M. Ghesani, A. Karambelkar, A. Rapkiewicz, J. Weber and G. Rosen

    Citation: Clinical Sarcoma Research 2016 6:24

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  6. Content type: Case report

    Extracranial metastasis of malignant meningioma to soft tissues is extremely rare and its clinical, radiological and pathological features are not well-characterised.

    Authors: Catherine McCarthy, Monika Hofer, Marianna Vlychou, Robar Khundkar, Paul Critchley, Simon Cudlip, Olaf Ansorge and Nick A. Athanasou

    Citation: Clinical Sarcoma Research 2016 6:23

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  7. Content type: Research

    Imatinib mesylate (IM) is the preferred treatment for the majority of patients with metastatic gastrointestinal stromal tumour (GIST). Low trough IM concentration (Cmin) values have been associated with poor clin...

    Authors: Ivar Hompland, Øyvind Sverre Bruland, Kumari Ubhayasekhera, Jonas Bergquist and Kjetil Boye

    Citation: Clinical Sarcoma Research 2016 6:21

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  8. Content type: Case report

    Aggressive fibromatosis (AF), also known as desmoid tumor, is an uncommon soft tissue neoplasm. AF does not metastasize, but it is locally invasive and its propensity for recurrence after conservative resectio...

    Authors: Gulcan Bulut, Anil Ozluk, Atike Pınar Erdogan, Ruchan Uslu, Nevra Elmas and Burcak Karaca

    Citation: Clinical Sarcoma Research 2016 6:22

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  9. Content type: Review

    Soft tissue sarcomas (STS) are rare tumours arising in mesenchymal tissues, and can occur almost anywhere in the body. Their rarity, and the heterogeneity of subtype and location means that developing evidence...

    Authors: Adam Dangoor, Beatrice Seddon, Craig Gerrand, Robert Grimer, Jeremy Whelan and Ian Judson

    Citation: Clinical Sarcoma Research 2016 6:20

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  10. Content type: Case report

    Chordomas are rare malignant tumours of the axial skeleton and skull base supposed to arise from cellular remnants of the notochord. These tumours have the potential to metastasize (30–40 %), usually in the la...

    Authors: Astrid Lipplaa, Sander Dijkstra and Hans Gelderblom

    Citation: Clinical Sarcoma Research 2016 6:19

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  11. Content type: Research

    The role of age as a prognostic factor has been examined in single institutional studies and in larger data sets from the SEER database, showing a survival advantage for younger versus adult patients with syno...

    Authors: Bernadette Brennan, Charles Stiller, Robert Grimer, Nicola Dennis, John Broggio and Matthew Francis

    Citation: Clinical Sarcoma Research 2016 6:18

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  12. Content type: Research

    Previous studies on high grade sarcomas using mass spectrometry imaging showed proteasome activator complex subunit 1 (PSME1) to be associated with poor survival in soft tissue sarcoma patients. PSME1 is invol...

    Authors: Sha Lou, Arjen H. G. Cleven, Benjamin Balluff, Marieke de Graaff, Marie Kostine, Inge Briaire-de Bruijn, Liam A. McDonnell and Judith V. M. G. Bovée

    Citation: Clinical Sarcoma Research 2016 6:17

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  13. Content type: Review

    Denosumab is a monoclonal antibody to RANK ligand approved for use in giant cell tumour (GCT) of bone. Due to its efficacy, Denosumab is recommended as the first option in inoperable or metastatic GCT. Denosum...

    Authors: Czar Louie Gaston, Robert J. Grimer, Michael Parry, Silvia Stacchiotti, Angelo Paolo Dei Tos, Hans Gelderblom, Stefano Ferrari, Giacomo G. Baldi, Robin L. Jones, Sant Chawla, Paolo Casali, Axel LeCesne, Jean-Yves Blay, Sander P. D. Dijkstra, David M. Thomas and Piotr Rutkowski

    Citation: Clinical Sarcoma Research 2016 6:15

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  14. Content type: Case Report

    Solitary fibrous tumour (SFT) is a rare soft tissue sarcoma with a low metastatic potential. A higher metastatic rate is observed in the high-grade/dedifferentiated variant. The most common expected site of di...

    Authors: Vittoria Colia, Salvatore Provenzano, Carlo Morosi, Paola Collini, Salvatore Lorenzo Renne, Paolo G. Dagrada, Claudia Sangalli, Angelo Paolo Dei Tos, Andrea Marrari, Paolo G. Casali and Silvia Stacchiotti

    Citation: Clinical Sarcoma Research 2016 6:16

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  15. Content type: Research

    A chronic inflammatory cell infiltrate is commonly seen in response to primary malignant tumours of bone. This is known to contain tumour-associated macrophages (TAMs) and lymphocytes; dendritic cells (DCs) an...

    Authors: Y. Inagaki, E. Hookway, K. A. Williams, A. B. Hassan, U. Oppermann, Y. Tanaka, E. Soilleux and N. A. Athanasou

    Citation: Clinical Sarcoma Research 2016 6:13

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  16. Content type: Research

    Advances in treatment of sarcoma patients has prolonged survival but has led to increased disease- or treatment-related complications resulting in greater number of admissions to the intensive care unit (ICU)....

    Authors: Rohan Gupta, Neda Heshami, Chouhan Jay, Naveen Ramesh, Juhee Song, Xiudong Lei, Erfe Jean Rose, Kristen Carter, Dejka M. Araujo, Robert S. Benjamin, Shreyaskumar Patel, Joseph L. Nates and Vinod Ravi

    Citation: Clinical Sarcoma Research 2016 6:12

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  17. Content type: Research

    There is a paucity of data on the current management of patients with advanced soft tissue sarcoma (STS) in the Australian health care setting. This study utilised the Australian sarcoma database to evaluate t...

    Authors: Susie Bae, Philip Crowe, Raghu Gowda, Warren Joubert, Richard Carey-Smith, Paul Stalley and Jayesh Desai

    Citation: Clinical Sarcoma Research 2016 6:11

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  18. Content type: Research

    Most GISTs have mutations in KIT or PDGFRA. Patients with advanced GIST with KIT exon 9, PDGFRA mutation or WT for KIT and PDGFRA have a worse progression-free survival (PFS) compared to patients with KIT exon...

    Authors: Joan Maurel, Antonio López-Pousa, Silvia Calabuig, Silvia Bagué, Xavier Garcia del Muro, Xavier Sanjuan, Jordi Rubió-Casadevall, Miriam Cuatrecasas, Javier Martinez-Trufero, Carlos Horndler, Joaquin Fra, Claudia Valverde, Andrés Redondo, Andrés Poveda, Isabel Sevilla, Nuria Lainez…

    Citation: Clinical Sarcoma Research 2016 6:10

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  19. Content type: Review

    Sarcomas are a heterogeneous group of mesenchymal malignancies. In recent years, studies have demonstrated that inhibition of angiogenic pathways or disruption of established vasculature can attenuate the grow...

    Authors: Kieuhoa T. Vo, Katherine K. Matthay and Steven G. DuBois

    Citation: Clinical Sarcoma Research 2016 6:9

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  20. Content type: Research

    Angiosarcoma is a rare subgroup of soft tissue sarcomas associated with poor prognosis, but paclitaxel has been shown to be active in pretreated metastatic disease. We investigated the efficacy and safety of w...

    Authors: Seonggyu Byeon, Haa-Na Song, Hee Kyung Kim, Jun Soo Ham, Su Jin Lee, Jeeyun Lee and Se Hoon Park

    Citation: Clinical Sarcoma Research 2016 6:8

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  21. Content type: Review

    This document is an update of the British Sarcoma Group guidelines published in 2010. The aim is to provide a reference standard for the clinical care of patients in the UK with bone sarcomas. Recent recommend...

    Authors: Craig Gerrand, Nick Athanasou, Bernadette Brennan, Robert Grimer, Ian Judson, Bruce Morland, David Peake, Beatrice Seddon and Jeremy Whelan

    Citation: Clinical Sarcoma Research 2016 6:7

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  22. Content type: Research

    Zoledronic acid (ZA) is a third-generation bisphosphonate in widespread clinical use to reduce pain and skeletal events in patients from a variety of malignancies with bone metastases. Pre-clinical studies ind...

    Authors: Robert M. Conry, Michael G. Rodriguez and Joseph G. Pressey

    Citation: Clinical Sarcoma Research 2016 6:6

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  23. Content type: Case Report

    Kaposi sarcoma is a neoplastic vascular disorder. It usually present on the skin of the upper and lower extremities, rarely in the mucosa of the head and neck. The most common sites reported are within the ora...

    Authors: Karima Mouden, Mouna Khmou, Saida Loughmari, Afaf Semmar, Hanan El Kacemi, Basma El Khannoussi, Tayeb Kebdani, Sanaa Elmajjaoui and Noureddine Benjaafar

    Citation: Clinical Sarcoma Research 2016 6:4

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  24. Content type: Meeting Report

    This report summarizes the results of the 3rd Joint ENCCA-WP7, EuroSarc, EEC, PROVABES, and EURAMOS European Bone Sarcoma Network Meeting, which was held at the Children’s Cancer Research Institute in Vienna, ...

    Authors: Leo Kager, Jeremy Whelan, Uta Dirksen, Bass Hassan, Jakob Anninga, Lindsey Bennister, Judith V. M. G. Bovée, Bernadette Brennan, Javier M. Broto, Laurence Brugières, Anne-Marie Cleton-Jansen, Christopher Copland, Aurélie Dutour, Franca Fagioli, Stefano Ferrari, Marta Fiocco…

    Citation: Clinical Sarcoma Research 2016 6:3

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  25. Content type: Case Report

    Abdominal leiomyosarcoma arising from the mesentery is a rare malignancy. It is an aggressive entity with an overall 5 year survival rate between 20 and 30 %. Surgical resection is the cornerstone of primary t...

    Authors: Mercy Varghese, Oyvind Bruland, Anne Marit Wiedswang, Ingvild Lobmaier, Bård Røsok, Robert S. Benjamin and Kirsten Sundby Hall

    Citation: Clinical Sarcoma Research 2016 6:2

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  26. Content type: Research

    Wide local excision with or without radiation therapy (RT) and chemotherapy is widely accepted as appropriate management for soft tissue sarcomas (STS) of the extremity. Although survival and local control rat...

    Authors: Michael Ziegele, David M. King and Manpreet Bedi

    Citation: Clinical Sarcoma Research 2016 6:1

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  27. Content type: Case Report

    Desmoid tumors are rare benign monoclonal fibroblastic tumors. Their aggressiveness is local with no potential for metastasis or dedifferentiation. Here we report on a 61-year-old patient who presented a local...

    Authors: François Bertucci, Marjorie Faure, Maria-Rosa Ghigna, Bruno Chetaille, Jérôme Guiramand, Laurence Moureau-Zabotto, Anthony Sarran and Delphine Perrot

    Citation: Clinical Sarcoma Research 2015 5:25

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  28. Content type: Case Report

    Rhabdomyosarcoma (RMS), a malignant tumour of mesenchymal origin which can occur at various sites in the body, is one of the most common soft tissue sarcomas in both children and adolescents, but is rare in ad...

    Authors: Panagiotis Karagiannis, Nina Guth, Gabriela B. Thoennissen, Christina Bern, Jan Sperveslage, Ilske Oschlies, Carsten Bokemeyer, Wolfram Klapper, Eva Wardelmann and Nils H. Thoennissen

    Citation: Clinical Sarcoma Research 2015 5:24

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  29. Content type: Research

    High-grade foci (grade 3 according to Broder’s grading system) are sometimes detected in low-grade (grade 1 and 2) central osteosarcoma. The aim of this study was to retrospectively evaluate the clinical outco...

    Authors: Alberto Righi, Anna Paioli, Angelo Paolo Dei Tos, Marco Gambarotti, Emanuela Palmerini, Manuela Cesari, Emanuela Marchesi, Davide Maria Donati, Piero Picci and Stefano Ferrari

    Citation: Clinical Sarcoma Research 2015 5:23

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  30. Content type: Case Report

    Pseudomyogenic hemangioendothelioma (PMH) is a recently described, indolent vascular tumor that usually presents in the distal extremities. PMH typically has a multi-focal presentation and can involve several ...

    Authors: Jason Joseph, Wei-lien Wang, Madhavi Patnana, Naveen Ramesh, Robert Benjamin, Shreyaskumar Patel and Vinod Ravi

    Citation: Clinical Sarcoma Research 2015 5:22

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  31. Content type: Case Report

    Gastrointestinal stromal tumors (GISTs) are commonly driven by activating mutations in either KIT or PDGFRA. Importantly, different mutations within these two genes can lead to very different levels of sensitivit...

    Authors: Andrew S. Brohl, Elizabeth G. Demicco, Karen Mourtzikos and Robert G. Maki

    Citation: Clinical Sarcoma Research 2015 5:21

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  32. Content type: Research

    Solitary fibrous tumors (SFT) of the retroperitoneum are rare spindle cell neoplasms, with a paucity of data on treatment outcomes. We hypothesized that surgical excision offered acceptable outcomes in SFTs.

    Authors: Rahul Rajeev, Mohit Patel, Thejus T. Jayakrishnan, Fabian M. Johnston, Meena Bedi, John Charlson and Kiran K. Turaga

    Citation: Clinical Sarcoma Research 2015 5:19

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  33. Content type: Research

    Venous thromboembolic co-morbidities can have a significant impact on treatment response, treatment options, quality of life, and ultimately, survival from cancer. There is a dearth of published information on...

    Authors: Sumitra Shantakumar, Alexandra Connelly-Frost, Monica G Kobayashi, Robert Allis and Li Li

    Citation: Clinical Sarcoma Research 2015 5:18

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  34. Content type: Research

    Chemotherapy in the multimodality treatment of osteosarcoma has improved survival. Reported outcomes on adult patients are limited. Poor necrosis rates post neoadjuvant chemotherapy (NAC) is considered an adve...

    Authors: G M O’Kane, K A Cadoo, E M Walsh, R Emerson, P Dervan, C O’Keane, B Hurson, G O’Toole, S Dudeney, E Kavanagh, S Eustace and D N Carney

    Citation: Clinical Sarcoma Research 2015 5:17

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  35. Content type: Research

    In vitro expanded mesenchymal stromal cells (MSCs) are increasingly used as experimental cellular therapy. However, there have been concerns regarding the safety of their use, particularly with regard to possi...

    Authors: Emilie P Buddingh, S Eriaty N Ruslan, Christianne M A Reijnders, Karoly Szuhai, Marieke L Kuijjer, Helene Roelofs, Pancras C W Hogendoorn, R Maarten Egeler, Anne-Marie Cleton-Jansen and Arjan C Lankester

    Citation: Clinical Sarcoma Research 2015 5:16

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  36. Content type: Case Report

    Tenosynovial giant cell tumour, diffuse type, also known under a variety of other terms including diffuse pigmented villonodular synovitis, tends to be locally aggressive and not infrequently can show multiple...

    Authors: A Righi, M Gambarotti, M Sbaraglia, T Frisoni, D Donati, D Vanel and A P Dei Tos

    Citation: Clinical Sarcoma Research 2015 5:15

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  37. Content type: Research

    Gemcitabine and docetaxel have been shown to be active in pre-treated relapsed leiomyosarcoma. This study investigated the combination as first line treatment in patients with unresectable locally advanced/met...

    Authors: Beatrice Seddon, Michelle Scurr, Robin L Jones, Zoe Wood, Cerys Propert-Lewis, Cyril Fisher, Adrienne Flanagan, Jonanthan Sunkersing, Roger A’Hern, Jeremy Whelan and Ian Judson

    Citation: Clinical Sarcoma Research 2015 5:13

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  38. Content type: Case Report

    Epithelioid hemangioendothelioma is a rare connective tissue tumor of vascular origin. It is most commonly found in young to middle aged women, and its clinical behavior is remakably variable from an indolent ...

    Authors: Olivia Bally, Louis Tassy, Bertrand Richioud, Anne-Valérie Decouvelaere, Jean-Yves Blay and Olfa Derbel

    Citation: Clinical Sarcoma Research 2015 5:12

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  39. Content type: Short Report

    To date, the pathomechanism of soft tissue sarcomas such as synovial sarcoma remains unclear whereas even a viral etiology was suspected. Aim of this study was to analyze whether EBV, HHV-8 or HPV play a role ...

    Authors: Ulrich Lenze, Florian Pohlig, Heinrich Mühlhofer, Florian Lenze, Andreas Toepfer, Hans Rechl, Rainer Burgkart, Rüdiger von Eisenhart-Rothe and Melanie Straub

    Citation: Clinical Sarcoma Research 2015 5:11

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  40. Content type: Research

    The efficacy and toxicity of first line palliative chemotherapy for soft tissue sarcomas (STS) in the elderly is poorly described.

    Authors: Nadia Yousaf, Samuel Harris, Juan Martin-Liberal, Susannah Stanway, Mark Linch, Maria Ifijen, Omar Al Muderis, Komel Khabra, Cyril Fisher, Jonathan Noujaim, Ian Judson and Charlotte Benson

    Citation: Clinical Sarcoma Research 2015 5:10

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  41. Content type: Case Report

    Conventional skeletal chondrosarcoma is a bone neoplasm, which is poorly sensitive to anthracyclines-based chemotherapy. We report on an 18-month-long tumour response to gemcitabine as single agent in a young ...

    Authors: Salvatore Provenzano, Nadia Hindi, Carlo Morosi, Mara Ghilardi, Paola Collini, Paolo G Casali and Silvia Stacchiotti

    Citation: Clinical Sarcoma Research 2015 5:9

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  42. Content type: Research

    Hormonal manipulation is sometimes recommended in the treatment of metastatic endometrial stromal sarcoma, but there are few data assessing the efficacy of endocrine therapies in this subtype of uterine sarcomas.

    Authors: Eirini Thanopoulou, Aleksandar Aleksic, Khin Thway, Komel Khabra and Ian Judson

    Citation: Clinical Sarcoma Research 2015 5:8

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  43. Content type: Research

    Recently a few cases of synovial sarcoma (SS) of the abdominal viscera have been reported, raising awareness about the potential for confusion between this entity and KIT-negative gastrointestinal stromal tumo...

    Authors: Salvatore Romeo, Sabrina Rossi, Marthelena Acosta Marín, Fabio Canal, Marta Sbaraglia, Licia Laurino, Guido Mazzoleni, Maria Cristina Montesco, Laura Valori, Marta Campo Dell’Orto, Andrea Gianatti, Alexander Joseph Lazar and Angelo Paolo Dei Tos

    Citation: Clinical Sarcoma Research 2015 5:7

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  44. Content type: Review

    Intra-osseous schwannoma is a rare mesenchymal tumor. Although, the head and neck region is one of the most common sites for schwannomas, its location at the skull bone is uncommon and accounted for less than ...

    Authors: Fadoua Rais, Naoual Benhmidou, Ghizlane Rais, Fadila Kouhen, Khadija Bellahamou, Hasna Loughlimi, Abdelhak Maghous, Sanae Elmejjaoui, Hanan Elkacemi, Tayeb Kebdani and Noureddine Benjaafar

    Citation: Clinical Sarcoma Research 2015 5:6

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  45. Content type: Research

    Solitary Fibrous Tumour (SFT) is a rare soft tissue neoplasm, described in several locations in the body. It is classified as intermediate malignant potential with low risk of metastasis and has a low tendency...

    Authors: Marco Maruzzo, Juan Martin-Liberal, Christina Messiou, Aisha Miah, Khin Thway, Rolyn Alvarado, Ian Judson and Charlotte Benson

    Citation: Clinical Sarcoma Research 2015 5:5

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