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  1. Review

    Current status and unanswered questions on the use of Denosumab in giant cell tumor of bone

    Denosumab is a monoclonal antibody to RANK ligand approved for use in giant cell tumour (GCT) of bone. Due to its efficacy, Denosumab is recommended as the first option in inoperable or metastatic GCT. Denosum...

    Czar Louie Gaston, Robert J. Grimer, Michael Parry, Silvia Stacchiotti, Angelo Paolo Dei Tos, Hans Gelderblom, Stefano Ferrari, Giacomo G. Baldi, Robin L. Jones, Sant Chawla, Paolo Casali, Axel LeCesne, Jean-Yves Blay, Sander P. D. Dijkstra, David M. Thomas and Piotr Rutkowski

    Clinical Sarcoma Research 2016 6:15

    Published on: 14 September 2016

  2. Case Report

    Solitary fibrous tumour presenting with a single bone metastasis: report of six cases and literature review

    Solitary fibrous tumour (SFT) is a rare soft tissue sarcoma with a low metastatic potential. A higher metastatic rate is observed in the high-grade/dedifferentiated variant. The most common expected site of di...

    Vittoria Colia, Salvatore Provenzano, Carlo Morosi, Paola Collini, Salvatore Lorenzo Renne, Paolo G. Dagrada, Claudia Sangalli, Angelo Paolo Dei Tos, Andrea Marrari, Paolo G. Casali and Silvia Stacchiotti

    Clinical Sarcoma Research 2016 6:16

    Published on: 1 September 2016

  3. Research

    Dendritic and mast cell involvement in the inflammatory response to primary malignant bone tumours

    A chronic inflammatory cell infiltrate is commonly seen in response to primary malignant tumours of bone. This is known to contain tumour-associated macrophages (TAMs) and lymphocytes; dendritic cells (DCs) an...

    Y. Inagaki, E. Hookway, K. A. Williams, A. B. Hassan, U. Oppermann, Y. Tanaka, E. Soilleux and N. A. Athanasou

    Clinical Sarcoma Research 2016 6:13

    Published on: 1 August 2016

  4. Research

    Predictors of survival in patients with sarcoma admitted to the intensive care unit

    Advances in treatment of sarcoma patients has prolonged survival but has led to increased disease- or treatment-related complications resulting in greater number of admissions to the intensive care unit (ICU)....

    Rohan Gupta, Neda Heshami, Chouhan Jay, Naveen Ramesh, Juhee Song, Xiudong Lei, Erfe Jean Rose, Kristen Carter, Dejka M. Araujo, Robert S. Benjamin, Shreyaskumar Patel, Joseph L. Nates and Vinod Ravi

    Clinical Sarcoma Research 2016 6:12

    Published on: 19 July 2016

  5. Research

    Patterns of care for patients with advanced soft tissue sarcoma: experience from Australian sarcoma services

    There is a paucity of data on the current management of patients with advanced soft tissue sarcoma (STS) in the Australian health care setting. This study utilised the Australian sarcoma database to evaluate t...

    Susie Bae, Philip Crowe, Raghu Gowda, Warren Joubert, Richard Carey-Smith, Paul Stalley and Jayesh Desai

    Clinical Sarcoma Research 2016 6:11

    Published on: 11 July 2016

  6. Research

    Phosphorylated-insulin growth factor I receptor (p-IGF1R) and metalloproteinase-3 (MMP3) expression in advanced gastrointestinal stromal tumors (GIST). A GEIS 19 study

    Most GISTs have mutations in KIT or PDGFRA. Patients with advanced GIST with KIT exon 9, PDGFRA mutation or WT for KIT and PDGFRA have a worse progression-free survival (PFS) compared to patients with KIT exon...

    Joan Maurel, Antonio López-Pousa, Silvia Calabuig, Silvia Bagué, Xavier Garcia del Muro, Xavier Sanjuan, Jordi Rubió-Casadevall, Miriam Cuatrecasas, Javier Martinez-Trufero, Carlos Horndler, Joaquin Fra, Claudia Valverde, Andrés Redondo, Andrés Poveda, Isabel Sevilla, Nuria Lainez…

    Clinical Sarcoma Research 2016 6:10

    Published on: 29 June 2016

  7. Research

    A Korean single-center, real-world, retrospective study of first-line weekly paclitaxel in patients with metastatic angiosarcoma

    Angiosarcoma is a rare subgroup of soft tissue sarcomas associated with poor prognosis, but paclitaxel has been shown to be active in pretreated metastatic disease. We investigated the efficacy and safety of w...

    Seonggyu Byeon, Haa-Na Song, Hee Kyung Kim, Jun Soo Ham, Su Jin Lee, Jeeyun Lee and Se Hoon Park

    Clinical Sarcoma Research 2016 6:8

    Published on: 5 May 2016

  8. Review

    UK guidelines for the management of bone sarcomas

    This document is an update of the British Sarcoma Group guidelines published in 2010. The aim is to provide a reference standard for the clinical care of patients in the UK with bone sarcomas. Recent recommend...

    Craig Gerrand, Nick Athanasou, Bernadette Brennan, Robert Grimer, Ian Judson, Bruce Morland, David Peake, Beatrice Seddon and Jeremy Whelan

    Clinical Sarcoma Research 2016 6:7

    Published on: 4 May 2016

  9. Case Report

    Proof of principle for bevacizumab activity in desmoid-type fibromatosis

    Desmoid-type fibromatosis (DF) is a rare disease, which often occurs in young adults. Medical treatment is an important option in the treatment algorithm of DF. Different chemotherapeutic regimens showed clini...

    Viktor Grünwald, Florian Länger, H. J. Raatschen and Andreas Beilken

    Clinical Sarcoma Research 2016 6:5

    Published on: 4 April 2016

  10. Case Report

    Primary Kaposi’s sarcoma of the nasal cavity: a case report and review of the literature

    Kaposi sarcoma is a neoplastic vascular disorder. It usually present on the skin of the upper and lower extremities, rarely in the mucosa of the head and neck. The most common sites reported are within the ora...

    Karima Mouden, Mouna Khmou, Saida Loughmari, Afaf Semmar, Hanan El Kacemi, Basma El Khannoussi, Tayeb Kebdani, Sanaa Elmajjaoui and Noureddine Benjaafar

    Clinical Sarcoma Research 2016 6:4

    Published on: 17 March 2016

  11. Meeting Report

    The ENCCA-WP7/EuroSarc/EEC/PROVABES/EURAMOS 3rd European Bone Sarcoma Networking Meeting/Joint Workshop of EU Bone Sarcoma Translational Research Networks; Vienna, Austria, September 24–25, 2015. Workshop Report

    This report summarizes the results of the 3rd Joint ENCCA-WP7, EuroSarc, EEC, PROVABES, and EURAMOS European Bone Sarcoma Network Meeting, which was held at the Children’s Cancer Research Institute in Vienna, ...

    Leo Kager, Jeremy Whelan, Uta Dirksen, Bass Hassan, Jakob Anninga, Lindsey Bennister, Judith V. M. G. Bovée, Bernadette Brennan, Javier M. Broto, Laurence Brugières, Anne-Marie Cleton-Jansen, Christopher Copland, Aurélie Dutour, Franca Fagioli, Stefano Ferrari, Marta Fiocco…

    Clinical Sarcoma Research 2016 6:3

    Published on: 16 March 2016

  12. Case Report

    Metastatic mesenteric dedifferentiated leiomyosarcoma: a case report and a review of literature

    Abdominal leiomyosarcoma arising from the mesentery is a rare malignancy. It is an aggressive entity with an overall 5 year survival rate between 20 and 30 %. Surgical resection is the cornerstone of primary t...

    Mercy Varghese, Oyvind Bruland, Anne Marit Wiedswang, Ingvild Lobmaier, Bård Røsok, Robert S. Benjamin and Kirsten Sundby Hall

    Clinical Sarcoma Research 2016 6:2

    Published on: 24 February 2016

  13. Research

    Tumor volume is a better predictor of post-operative wound complications compared to tumor size in soft tissue sarcomas of the proximal lower extremity

    Wide local excision with or without radiation therapy (RT) and chemotherapy is widely accepted as appropriate management for soft tissue sarcomas (STS) of the extremity. Although survival and local control rat...

    Michael Ziegele, David M. King and Manpreet Bedi

    Clinical Sarcoma Research 2016 6:1

    Published on: 22 February 2016

  14. Case Report

    High-grade soft tissue sarcoma arising in a desmoid tumor: case report and review of the literature

    Desmoid tumors are rare benign monoclonal fibroblastic tumors. Their aggressiveness is local with no potential for metastasis or dedifferentiation. Here we report on a 61-year-old patient who presented a local...

    François Bertucci, Marjorie Faure, Maria-Rosa Ghigna, Bruno Chetaille, Jérôme Guiramand, Laurence Moureau-Zabotto, Anthony Sarran and Delphine Perrot

    Clinical Sarcoma Research 2015 5:25

    Published on: 30 November 2015

  15. Case Report

    Alveolar rhabdomyosarcoma confined to the bone marrow with no identifiable primary tumour using FDG-PET/CT

    Rhabdomyosarcoma (RMS), a malignant tumour of mesenchymal origin which can occur at various sites in the body, is one of the most common soft tissue sarcomas in both children and adolescents, but is rare in ad...

    Panagiotis Karagiannis, Nina Guth, Gabriela B. Thoennissen, Christina Bern, Jan Sperveslage, Ilske Oschlies, Carsten Bokemeyer, Wolfram Klapper, Eva Wardelmann and Nils H. Thoennissen

    Clinical Sarcoma Research 2015 5:24

    Published on: 19 November 2015

  16. Research

    High-grade focal areas in low-grade central osteosarcoma: high-grade or still low-grade osteosarcoma?

    High-grade foci (grade 3 according to Broder’s grading system) are sometimes detected in low-grade (grade 1 and 2) central osteosarcoma. The aim of this study was to retrospectively evaluate the clinical outco...

    Alberto Righi, Anna Paioli, Angelo Paolo Dei Tos, Marco Gambarotti, Emanuela Palmerini, Manuela Cesari, Emanuela Marchesi, Davide Maria Donati, Piero Picci and Stefano Ferrari

    Clinical Sarcoma Research 2015 5:23

    Published on: 29 October 2015

  17. Case Report

    Cytotoxic and targeted therapy for treatment of pseudomyogenic hemangioendothelioma

    Pseudomyogenic hemangioendothelioma (PMH) is a recently described, indolent vascular tumor that usually presents in the distal extremities. PMH typically has a multi-focal presentation and can involve several ...

    Jason Joseph, Wei-lien Wang, Madhavi Patnana, Naveen Ramesh, Robert Benjamin, Shreyaskumar Patel and Vinod Ravi

    Clinical Sarcoma Research 2015 5:22

    Published on: 19 October 2015

  18. Research

    Retroperitoneal solitary fibrous tumor: surgery as first line therapy

    Solitary fibrous tumors (SFT) of the retroperitoneum are rare spindle cell neoplasms, with a paucity of data on treatment outcomes. We hypothesized that surgical excision offered acceptable outcomes in SFTs.

    Rahul Rajeev, Mohit Patel, Thejus T. Jayakrishnan, Fabian M. Johnston, Meena Bedi, John Charlson and Kiran K. Turaga

    Clinical Sarcoma Research 2015 5:19

    Published on: 27 August 2015

  19. Research

    Older soft tissue sarcoma patients experience increased rates of venous thromboembolic events: a retrospective cohort study of SEER-Medicare data

    Venous thromboembolic co-morbidities can have a significant impact on treatment response, treatment options, quality of life, and ultimately, survival from cancer. There is a dearth of published information on...

    Sumitra Shantakumar, Alexandra Connelly-Frost, Monica G Kobayashi, Robert Allis and Li Li

    Clinical Sarcoma Research 2015 5:18

    Published on: 26 July 2015

  20. Research

    Perioperative chemotherapy in the treatment of osteosarcoma: a 26-year single institution review

    Chemotherapy in the multimodality treatment of osteosarcoma has improved survival. Reported outcomes on adult patients are limited. Poor necrosis rates post neoadjuvant chemotherapy (NAC) is considered an adve...

    G M O’Kane, K A Cadoo, E M Walsh, R Emerson, P Dervan, C O’Keane, B Hurson, G O’Toole, S Dudeney, E Kavanagh, S Eustace and D N Carney

    Clinical Sarcoma Research 2015 5:17

    Published on: 14 July 2015

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