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  1. Content type: Research

    Previous studies on high grade sarcomas using mass spectrometry imaging showed proteasome activator complex subunit 1 (PSME1) to be associated with poor survival in soft tissue sarcoma patients. PSME1 is invol...

    Authors: Sha Lou, Arjen H. G. Cleven, Benjamin Balluff, Marieke de Graaff, Marie Kostine, Inge Briaire-de Bruijn, Liam A. McDonnell and Judith V. M. G. Bovée

    Citation: Clinical Sarcoma Research 2016 6:17

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  2. Content type: Review

    Denosumab is a monoclonal antibody to RANK ligand approved for use in giant cell tumour (GCT) of bone. Due to its efficacy, Denosumab is recommended as the first option in inoperable or metastatic GCT. Denosum...

    Authors: Czar Louie Gaston, Robert J. Grimer, Michael Parry, Silvia Stacchiotti, Angelo Paolo Dei Tos, Hans Gelderblom, Stefano Ferrari, Giacomo G. Baldi, Robin L. Jones, Sant Chawla, Paolo Casali, Axel LeCesne, Jean-Yves Blay, Sander P. D. Dijkstra, David M. Thomas and Piotr Rutkowski

    Citation: Clinical Sarcoma Research 2016 6:15

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  3. Content type: Case Report

    Solitary fibrous tumour (SFT) is a rare soft tissue sarcoma with a low metastatic potential. A higher metastatic rate is observed in the high-grade/dedifferentiated variant. The most common expected site of di...

    Authors: Vittoria Colia, Salvatore Provenzano, Carlo Morosi, Paola Collini, Salvatore Lorenzo Renne, Paolo G. Dagrada, Claudia Sangalli, Angelo Paolo Dei Tos, Andrea Marrari, Paolo G. Casali and Silvia Stacchiotti

    Citation: Clinical Sarcoma Research 2016 6:16

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  4. Content type: Research

    A chronic inflammatory cell infiltrate is commonly seen in response to primary malignant tumours of bone. This is known to contain tumour-associated macrophages (TAMs) and lymphocytes; dendritic cells (DCs) an...

    Authors: Y. Inagaki, E. Hookway, K. A. Williams, A. B. Hassan, U. Oppermann, Y. Tanaka, E. Soilleux and N. A. Athanasou

    Citation: Clinical Sarcoma Research 2016 6:13

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  5. Content type: Research

    Advances in treatment of sarcoma patients has prolonged survival but has led to increased disease- or treatment-related complications resulting in greater number of admissions to the intensive care unit (ICU)....

    Authors: Rohan Gupta, Neda Heshami, Chouhan Jay, Naveen Ramesh, Juhee Song, Xiudong Lei, Erfe Jean Rose, Kristen Carter, Dejka M. Araujo, Robert S. Benjamin, Shreyaskumar Patel, Joseph L. Nates and Vinod Ravi

    Citation: Clinical Sarcoma Research 2016 6:12

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  6. Content type: Research

    There is a paucity of data on the current management of patients with advanced soft tissue sarcoma (STS) in the Australian health care setting. This study utilised the Australian sarcoma database to evaluate t...

    Authors: Susie Bae, Philip Crowe, Raghu Gowda, Warren Joubert, Richard Carey-Smith, Paul Stalley and Jayesh Desai

    Citation: Clinical Sarcoma Research 2016 6:11

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  7. Content type: Research

    Most GISTs have mutations in KIT or PDGFRA. Patients with advanced GIST with KIT exon 9, PDGFRA mutation or WT for KIT and PDGFRA have a worse progression-free survival (PFS) compared to patients with KIT exon...

    Authors: Joan Maurel, Antonio López-Pousa, Silvia Calabuig, Silvia Bagué, Xavier Garcia del Muro, Xavier Sanjuan, Jordi Rubió-Casadevall, Miriam Cuatrecasas, Javier Martinez-Trufero, Carlos Horndler, Joaquin Fra, Claudia Valverde, Andrés Redondo, Andrés Poveda, Isabel Sevilla, Nuria Lainez…

    Citation: Clinical Sarcoma Research 2016 6:10

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  8. Content type: Review

    Sarcomas are a heterogeneous group of mesenchymal malignancies. In recent years, studies have demonstrated that inhibition of angiogenic pathways or disruption of established vasculature can attenuate the grow...

    Authors: Kieuhoa T. Vo, Katherine K. Matthay and Steven G. DuBois

    Citation: Clinical Sarcoma Research 2016 6:9

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  9. Content type: Research

    Angiosarcoma is a rare subgroup of soft tissue sarcomas associated with poor prognosis, but paclitaxel has been shown to be active in pretreated metastatic disease. We investigated the efficacy and safety of w...

    Authors: Seonggyu Byeon, Haa-Na Song, Hee Kyung Kim, Jun Soo Ham, Su Jin Lee, Jeeyun Lee and Se Hoon Park

    Citation: Clinical Sarcoma Research 2016 6:8

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  10. Content type: Review

    This document is an update of the British Sarcoma Group guidelines published in 2010. The aim is to provide a reference standard for the clinical care of patients in the UK with bone sarcomas. Recent recommend...

    Authors: Craig Gerrand, Nick Athanasou, Bernadette Brennan, Robert Grimer, Ian Judson, Bruce Morland, David Peake, Beatrice Seddon and Jeremy Whelan

    Citation: Clinical Sarcoma Research 2016 6:7

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  11. Content type: Research

    Zoledronic acid (ZA) is a third-generation bisphosphonate in widespread clinical use to reduce pain and skeletal events in patients from a variety of malignancies with bone metastases. Pre-clinical studies ind...

    Authors: Robert M. Conry, Michael G. Rodriguez and Joseph G. Pressey

    Citation: Clinical Sarcoma Research 2016 6:6

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  12. Content type: Case Report

    Kaposi sarcoma is a neoplastic vascular disorder. It usually present on the skin of the upper and lower extremities, rarely in the mucosa of the head and neck. The most common sites reported are within the ora...

    Authors: Karima Mouden, Mouna Khmou, Saida Loughmari, Afaf Semmar, Hanan El Kacemi, Basma El Khannoussi, Tayeb Kebdani, Sanaa Elmajjaoui and Noureddine Benjaafar

    Citation: Clinical Sarcoma Research 2016 6:4

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  13. Content type: Meeting Report

    This report summarizes the results of the 3rd Joint ENCCA-WP7, EuroSarc, EEC, PROVABES, and EURAMOS European Bone Sarcoma Network Meeting, which was held at the Children’s Cancer Research Institute in Vienna, ...

    Authors: Leo Kager, Jeremy Whelan, Uta Dirksen, Bass Hassan, Jakob Anninga, Lindsey Bennister, Judith V. M. G. Bovée, Bernadette Brennan, Javier M. Broto, Laurence Brugières, Anne-Marie Cleton-Jansen, Christopher Copland, Aurélie Dutour, Franca Fagioli, Stefano Ferrari, Marta Fiocco…

    Citation: Clinical Sarcoma Research 2016 6:3

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  14. Content type: Case Report

    Abdominal leiomyosarcoma arising from the mesentery is a rare malignancy. It is an aggressive entity with an overall 5 year survival rate between 20 and 30 %. Surgical resection is the cornerstone of primary t...

    Authors: Mercy Varghese, Oyvind Bruland, Anne Marit Wiedswang, Ingvild Lobmaier, Bård Røsok, Robert S. Benjamin and Kirsten Sundby Hall

    Citation: Clinical Sarcoma Research 2016 6:2

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  15. Content type: Research

    Wide local excision with or without radiation therapy (RT) and chemotherapy is widely accepted as appropriate management for soft tissue sarcomas (STS) of the extremity. Although survival and local control rat...

    Authors: Michael Ziegele, David M. King and Manpreet Bedi

    Citation: Clinical Sarcoma Research 2016 6:1

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  16. Content type: Case Report

    Desmoid tumors are rare benign monoclonal fibroblastic tumors. Their aggressiveness is local with no potential for metastasis or dedifferentiation. Here we report on a 61-year-old patient who presented a local...

    Authors: François Bertucci, Marjorie Faure, Maria-Rosa Ghigna, Bruno Chetaille, Jérôme Guiramand, Laurence Moureau-Zabotto, Anthony Sarran and Delphine Perrot

    Citation: Clinical Sarcoma Research 2015 5:25

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  17. Content type: Case Report

    Rhabdomyosarcoma (RMS), a malignant tumour of mesenchymal origin which can occur at various sites in the body, is one of the most common soft tissue sarcomas in both children and adolescents, but is rare in ad...

    Authors: Panagiotis Karagiannis, Nina Guth, Gabriela B. Thoennissen, Christina Bern, Jan Sperveslage, Ilske Oschlies, Carsten Bokemeyer, Wolfram Klapper, Eva Wardelmann and Nils H. Thoennissen

    Citation: Clinical Sarcoma Research 2015 5:24

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  18. Content type: Research

    High-grade foci (grade 3 according to Broder’s grading system) are sometimes detected in low-grade (grade 1 and 2) central osteosarcoma. The aim of this study was to retrospectively evaluate the clinical outco...

    Authors: Alberto Righi, Anna Paioli, Angelo Paolo Dei Tos, Marco Gambarotti, Emanuela Palmerini, Manuela Cesari, Emanuela Marchesi, Davide Maria Donati, Piero Picci and Stefano Ferrari

    Citation: Clinical Sarcoma Research 2015 5:23

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  19. Content type: Case Report

    Pseudomyogenic hemangioendothelioma (PMH) is a recently described, indolent vascular tumor that usually presents in the distal extremities. PMH typically has a multi-focal presentation and can involve several ...

    Authors: Jason Joseph, Wei-lien Wang, Madhavi Patnana, Naveen Ramesh, Robert Benjamin, Shreyaskumar Patel and Vinod Ravi

    Citation: Clinical Sarcoma Research 2015 5:22

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  20. Content type: Case Report

    Gastrointestinal stromal tumors (GISTs) are commonly driven by activating mutations in either KIT or PDGFRA. Importantly, different mutations within these two genes can lead to very different levels of sensitivit...

    Authors: Andrew S. Brohl, Elizabeth G. Demicco, Karen Mourtzikos and Robert G. Maki

    Citation: Clinical Sarcoma Research 2015 5:21

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  21. Content type: Research

    Solitary fibrous tumors (SFT) of the retroperitoneum are rare spindle cell neoplasms, with a paucity of data on treatment outcomes. We hypothesized that surgical excision offered acceptable outcomes in SFTs.

    Authors: Rahul Rajeev, Mohit Patel, Thejus T. Jayakrishnan, Fabian M. Johnston, Meena Bedi, John Charlson and Kiran K. Turaga

    Citation: Clinical Sarcoma Research 2015 5:19

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  22. Content type: Research

    Venous thromboembolic co-morbidities can have a significant impact on treatment response, treatment options, quality of life, and ultimately, survival from cancer. There is a dearth of published information on...

    Authors: Sumitra Shantakumar, Alexandra Connelly-Frost, Monica G Kobayashi, Robert Allis and Li Li

    Citation: Clinical Sarcoma Research 2015 5:18

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  23. Content type: Research

    Chemotherapy in the multimodality treatment of osteosarcoma has improved survival. Reported outcomes on adult patients are limited. Poor necrosis rates post neoadjuvant chemotherapy (NAC) is considered an adve...

    Authors: G M O’Kane, K A Cadoo, E M Walsh, R Emerson, P Dervan, C O’Keane, B Hurson, G O’Toole, S Dudeney, E Kavanagh, S Eustace and D N Carney

    Citation: Clinical Sarcoma Research 2015 5:17

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  24. Content type: Research

    In vitro expanded mesenchymal stromal cells (MSCs) are increasingly used as experimental cellular therapy. However, there have been concerns regarding the safety of their use, particularly with regard to possi...

    Authors: Emilie P Buddingh, S Eriaty N Ruslan, Christianne M A Reijnders, Karoly Szuhai, Marieke L Kuijjer, Helene Roelofs, Pancras C W Hogendoorn, R Maarten Egeler, Anne-Marie Cleton-Jansen and Arjan C Lankester

    Citation: Clinical Sarcoma Research 2015 5:16

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  25. Content type: Case Report

    Tenosynovial giant cell tumour, diffuse type, also known under a variety of other terms including diffuse pigmented villonodular synovitis, tends to be locally aggressive and not infrequently can show multiple...

    Authors: A Righi, M Gambarotti, M Sbaraglia, T Frisoni, D Donati, D Vanel and A P Dei Tos

    Citation: Clinical Sarcoma Research 2015 5:15

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  26. Content type: Research

    Gemcitabine and docetaxel have been shown to be active in pre-treated relapsed leiomyosarcoma. This study investigated the combination as first line treatment in patients with unresectable locally advanced/met...

    Authors: Beatrice Seddon, Michelle Scurr, Robin L Jones, Zoe Wood, Cerys Propert-Lewis, Cyril Fisher, Adrienne Flanagan, Jonanthan Sunkersing, Roger A’Hern, Jeremy Whelan and Ian Judson

    Citation: Clinical Sarcoma Research 2015 5:13

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  27. Content type: Case Report

    Epithelioid hemangioendothelioma is a rare connective tissue tumor of vascular origin. It is most commonly found in young to middle aged women, and its clinical behavior is remakably variable from an indolent ...

    Authors: Olivia Bally, Louis Tassy, Bertrand Richioud, Anne-Valérie Decouvelaere, Jean-Yves Blay and Olfa Derbel

    Citation: Clinical Sarcoma Research 2015 5:12

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  28. Content type: Short Report

    To date, the pathomechanism of soft tissue sarcomas such as synovial sarcoma remains unclear whereas even a viral etiology was suspected. Aim of this study was to analyze whether EBV, HHV-8 or HPV play a role ...

    Authors: Ulrich Lenze, Florian Pohlig, Heinrich Mühlhofer, Florian Lenze, Andreas Toepfer, Hans Rechl, Rainer Burgkart, Rüdiger von Eisenhart-Rothe and Melanie Straub

    Citation: Clinical Sarcoma Research 2015 5:11

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  29. Content type: Research

    The efficacy and toxicity of first line palliative chemotherapy for soft tissue sarcomas (STS) in the elderly is poorly described.

    Authors: Nadia Yousaf, Samuel Harris, Juan Martin-Liberal, Susannah Stanway, Mark Linch, Maria Ifijen, Omar Al Muderis, Komel Khabra, Cyril Fisher, Jonathan Noujaim, Ian Judson and Charlotte Benson

    Citation: Clinical Sarcoma Research 2015 5:10

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  30. Content type: Case Report

    Conventional skeletal chondrosarcoma is a bone neoplasm, which is poorly sensitive to anthracyclines-based chemotherapy. We report on an 18-month-long tumour response to gemcitabine as single agent in a young ...

    Authors: Salvatore Provenzano, Nadia Hindi, Carlo Morosi, Mara Ghilardi, Paola Collini, Paolo G Casali and Silvia Stacchiotti

    Citation: Clinical Sarcoma Research 2015 5:9

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  31. Content type: Research

    Hormonal manipulation is sometimes recommended in the treatment of metastatic endometrial stromal sarcoma, but there are few data assessing the efficacy of endocrine therapies in this subtype of uterine sarcomas.

    Authors: Eirini Thanopoulou, Aleksandar Aleksic, Khin Thway, Komel Khabra and Ian Judson

    Citation: Clinical Sarcoma Research 2015 5:8

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  32. Content type: Research

    Recently a few cases of synovial sarcoma (SS) of the abdominal viscera have been reported, raising awareness about the potential for confusion between this entity and KIT-negative gastrointestinal stromal tumo...

    Authors: Salvatore Romeo, Sabrina Rossi, Marthelena Acosta Marín, Fabio Canal, Marta Sbaraglia, Licia Laurino, Guido Mazzoleni, Maria Cristina Montesco, Laura Valori, Marta Campo Dell’Orto, Andrea Gianatti, Alexander Joseph Lazar and Angelo Paolo Dei Tos

    Citation: Clinical Sarcoma Research 2015 5:7

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  33. Content type: Review

    Intra-osseous schwannoma is a rare mesenchymal tumor. Although, the head and neck region is one of the most common sites for schwannomas, its location at the skull bone is uncommon and accounted for less than ...

    Authors: Fadoua Rais, Naoual Benhmidou, Ghizlane Rais, Fadila Kouhen, Khadija Bellahamou, Hasna Loughlimi, Abdelhak Maghous, Sanae Elmejjaoui, Hanan Elkacemi, Tayeb Kebdani and Noureddine Benjaafar

    Citation: Clinical Sarcoma Research 2015 5:6

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  34. Content type: Research

    Solitary Fibrous Tumour (SFT) is a rare soft tissue neoplasm, described in several locations in the body. It is classified as intermediate malignant potential with low risk of metastasis and has a low tendency...

    Authors: Marco Maruzzo, Juan Martin-Liberal, Christina Messiou, Aisha Miah, Khin Thway, Rolyn Alvarado, Ian Judson and Charlotte Benson

    Citation: Clinical Sarcoma Research 2015 5:5

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  35. Content type: Short Report

    Osteosarcoma is the most common primary malignant bone tumor in children and young adults. Ganglioside GD2 has been previously found on the cell surface in various tumor types, including osteosarcomas.

    Authors: Vincent I Poon, Michael Roth, Sajida Piperdi, David Geller, Jonathan Gill, Erin R Rudzinski, Douglas S Hawkins and Richard Gorlick

    Citation: Clinical Sarcoma Research 2015 5:4

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  36. Content type: Research

    Pulmonary artery sarcoma (PAS) is a rare but aggressive malignancy that leads to heart failure and death without treatment. Here we reviewed the presentation and management of patients treated at a national ce...

    Authors: Han Hsi Wong, Ioannis Gounaris, Ann McCormack, Marius Berman, Dochka Davidson, Gail Horan, Joanna Pepke-Zaba, David Jenkins, Helena M Earl and Helen M Hatcher

    Citation: Clinical Sarcoma Research 2015 5:3

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  37. Content type: Research

    Tyrosine kinase inhibitors (TKI) have revolutionized the treatment of gastrointestinal

    Authors: Attila Kollàr, Marco Maruzzo, Christina Messiou, Elisabeth Cartwright, Aisha Miah, Juan Martin-Liberal, Khin Thway, Ellen McGrath, Alison Dunlop, Komel Khabra, Beatrice Seddon, Palma Dileo, Mark Linch, Ian Judson and Charlotte Benson

    Citation: Clinical Sarcoma Research 2014 4:17

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  38. Content type: Research

    Liposarcomas represent the most common histological type of soft-tissue sarcomas (STS). Its main subgroups, WD/DD, is known to be poorly sensitive to chemotherapy, with few active agents, i.e., anthracyclines ...

    Authors: Roberta Sanfilippo, Rossella Bertulli, Andrea Marrari, Elena Fumagalli, Silvana Pilotti, Carlo Morosi, Antonella Messina, Angelo Paolo Dei Tos, Alessandro Gronchi and Paolo Giovanni Casali

    Citation: Clinical Sarcoma Research 2014 4:16

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  39. Content type: Case Report

    An increased risk of posttransplant malignancy has been consistently reported following various solid organ transplants. The malignancies most commonly encountered are non-melanoma skin cancers, carcinomas of ...

    Authors: Lea N Baer, David G Savage, Hanina H Hibshoosh and Kevin Kalinsky

    Citation: Clinical Sarcoma Research 2014 4:15

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  40. Content type: Case Report

    Recently, the phase III PALETTE study introduced pazopanib (Votrient®) as treatment for adult patients with locally advanced or metastatic non-liposarcoma soft tissue sarcoma after prior treatment with doxorub...

    Authors: Arie J Verschoor and Hans Gelderblom

    Citation: Clinical Sarcoma Research 2014 4:14

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  41. Content type: Case Report

    Hemangiopericytoma is a rare disease entity of soft-tissue sarcoma (STS) that can be cured with surgical resection. In cases of inoperable recurrence or metastasis, palliative chemotherapy is indicated, though...

    Authors: Su Jin Lee, Seung Tae Kim, Se Hoon Park, Yoon La Choi, Jae Berm Park, Sung-Joo Kim and Jeeyun Lee

    Citation: Clinical Sarcoma Research 2014 4:13

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  42. Content type: Case Report

    We report multiple synchronous clear-cell chondrosarcomas in a 43-year-old patient. The patient had a lesion in the right proximal humerus and in the left femoral condyle. Bone scintigraphy revealed increased ...

    Authors: Marco Manfrini, Silvana Fiscina, Alberto Righi, Jorge M Montes and Daniel Vanel

    Citation: Clinical Sarcoma Research 2014 4:12

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  43. Content type: Research

    The majority of patients with chondrosarcoma of bone have an excellent overall survival after local therapy. However, in case of unresectable locally advanced or metastatic disease the outcome is poor and limi...

    Authors: Annemiek M van Maldegem, Judith VMG Bovée and Hans Gelderblom

    Citation: Clinical Sarcoma Research 2014 4:11

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  44. Content type: Research

    Acquired resistance to tyrosine kinase inhibitors (TKIs) in gastrointestinal stromal tumours (GISTs) is most commonly caused by secondary KIT or PDGFRA mutations. In this study we characterize a newly established...

    Authors: Thomas Van Looy, Yemarshet Kelemework Gebreyohannes, Agnieszka Wozniak, Jasmien Cornillie, Jasmien Wellens, Haifu Li, Ulla Vanleeuw, Giuseppe Floris, Maria Debiec-Rychter, Raf Sciot and Patrick Schöffski

    Citation: Clinical Sarcoma Research 2014 4:10

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  45. Content type: Short Report

    Intragenic deletions of the dystrophin-encoding and muscular dystrophy-associated DMD gene have been recently described in gastrointestinal stromal tumor (GIST), rhabdomyosarcoma (RMS) and leiomyosarcoma (LMS). W...

    Authors: Maria A Pantaleo, Annalisa Astolfi, Milena Urbini, Fabio Fuligni, Maristella Saponara, Margherita Nannini, Cristian Lolli, Valentina Indio, Donatella Santini, Giorgio Ercolani, Giovanni Brandi, Antonio D Pinna and Guido Biasco

    Citation: Clinical Sarcoma Research 2014 4:9

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  46. Content type: Case Report

    Dermatofibrosarcoma Protuberans (DFSP) is a rare skin tumor, characterized by frequent local recurrence but is seldom metastatic. It is histologically characterized by storiform arrangement of spindle cells. C...

    Authors: Mashaal Dhir, David G Crockett, Todd M Stevens, Peter T Silberstein, William J Hunter and Jason M Foster

    Citation: Clinical Sarcoma Research 2014 4:8

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